Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer
ghareeb, A., Mohamed, R., Abd el fattah, A., saadawy, S. (2020). Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer. EKB Journal Management System, 26(6), 919-927. doi: 10.21608/zumj.2019.14149.1292
amal fathy ghareeb; Randa Husseiny Mohamed; Ahmed Raafat Abd el fattah; sara fouad saadawy. "Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer". EKB Journal Management System, 26, 6, 2020, 919-927. doi: 10.21608/zumj.2019.14149.1292
ghareeb, A., Mohamed, R., Abd el fattah, A., saadawy, S. (2020). 'Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer', EKB Journal Management System, 26(6), pp. 919-927. doi: 10.21608/zumj.2019.14149.1292
ghareeb, A., Mohamed, R., Abd el fattah, A., saadawy, S. Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer. EKB Journal Management System, 2020; 26(6): 919-927. doi: 10.21608/zumj.2019.14149.1292

Association between serum microrna-21 gene expression , carcinoemberyonic antigen and clinicopathological character for colorectal cancer

Zagazig University Medical Journal
Article 4, Volume 26, Issue 6, November 2020, Pages 919-927    PDF (556.04 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.14149.1292
Authors
amal fathy ghareeb1; Randa Husseiny Mohamed2; Ahmed Raafat Abd el fattah3; sara fouad saadawy* 4
1medical biochemistry,medicine,zagazig
2medical biochemistry department/faculty of medicine/ zagzazig university /zagazig / sharkia
3General SurgeryDepartment, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4medical biochemistry department /faculty of medicine/zagazig university/zagazig /sharkia
Abstract
Background and objetives: MicroRNAs (miRNAs) are small, noncoding RNAs that are involved in carcinogenesis through postranscriptional gene regulatory activity. The current study aimed to measure serum miR-21 expression levels and to evaluate their association with the outcome of colorectal cancer (CRC) and correlate it with carcinoemberyonic antigen level.
Methods: Blood samples were collected from 48 CRC patients and 48 healthy controls. The expression levels of miR-21 were measured using a quantitative reverse transcription polymerase chain reaction (qRT-PCR).The results were analysed to assess the relationship between serum miR-21 levels and clinic pathological and prognostic factors.
Results: A univariate analysis revealed that high expression levels of serum miR-21 were associated with higher local recurrence , TNM staging, PT staging ,venous invasion ,liver metastasis and recurrane (p=0.004),positively correlated with CEA.
Conclusion: The expression level of serum miR-21 correlates with CEA, recurrence and some pathological parameters of CRC patients. Our results suggest that circulating serum miR-21 is a promising prognostic tumour marker, and they highlight the potential clinical utility of miR-21 expression as a diagnostic and prognostic marker for CRC prognosis.
Keywords
MicroRNA-21; CEA; colorectal cancer; correlation
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