Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio)
et al., N. (2025). Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio). EKB Journal Management System, 29(2), 1173-1180. doi: 10.21608/ejabf.2025.419336
Noomi et al.. "Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio)". EKB Journal Management System, 29, 2, 2025, 1173-1180. doi: 10.21608/ejabf.2025.419336
et al., N. (2025). 'Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio)', EKB Journal Management System, 29(2), pp. 1173-1180. doi: 10.21608/ejabf.2025.419336
et al., N. Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio). EKB Journal Management System, 2025; 29(2): 1173-1180. doi: 10.21608/ejabf.2025.419336

Preventive and Ameliorative Role of Lactoferrin in Improving Blood, Lipid and Liver Profiles Toward Immune Homeostasis in Lipopolysaccharides (LPS) Induced Dysregulation of Bio-Vital Parameters in the Common Carp (Cyprinus carpio)

Egyptian Journal of Aquatic Biology and Fisheries
Article 85, Volume 29, Issue 2, March and April 2025, Page 1173-1180  XML PDF (251.46 K)
DOI: 10.21608/ejabf.2025.419336
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Author
Noomi et al.
Abstract
This study investigated preventive and ameliorative roles of lactoferrin against LPS induced inflammation in fish common carps. A total of 160 fish were used in this study. Forty common carps were divided equally into 4 groups: control group, control treated with LF group (LF group), LPS group (LPS only) and LPS treated with LF (LPS+LF). The results showed both preventive and protective roles of LF in both LF alone and LPS+LF, respectively. Both preventive and protective role recorded an enhancing effect of LF with a dose of 6g/ kg, which was enough for restoring the liver, blood as well as lipid profiles against LPS (3μg/ ml) induced dysregulation of the bio-vital parameters. In the liver, which is one of the major organs involving in innate and adaptive immunity, a significant change was detected in the ALP, ALT and AST. On the other hand, LF regulated the lipid profile, including cholesterol, triglycerides, LDL and HDL. Additionally, LF was recorded with a significant enhancement and restoration in blood profile including RBCs, WBCs and globulin. Totally, these results suggested the enhancement role of the LF which leads to improvement of the immune- bio-vital status of the body through restoring the liver, lipid and blood profile, suggesting a beneficial and preventive role of lactoferrin as a main source for maintaining and improving industry of the aquatic life in the future.
Keywords
Blood; Lactoferrin; Lipopolysaccharides Lipid; Liver
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