Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture
Sherif, M., Karam, K., Abd Elbaset, Z., Iskandarani, D., Iskandarani, Y. (2025). Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture. EKB Journal Management System, 4(1), 154-166. doi: 10.21608/ermhs.2025.371187.1051
Maher Abd Elhmmed Sherif; Khalid Abd Elkarim Karam; Zakaria Moh Abd Elbaset; Dalya Ayman Iskandarani; Yara Ayman Iskandarani. "Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture". EKB Journal Management System, 4, 1, 2025, 154-166. doi: 10.21608/ermhs.2025.371187.1051
Sherif, M., Karam, K., Abd Elbaset, Z., Iskandarani, D., Iskandarani, Y. (2025). 'Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture', EKB Journal Management System, 4(1), pp. 154-166. doi: 10.21608/ermhs.2025.371187.1051
Sherif, M., Karam, K., Abd Elbaset, Z., Iskandarani, D., Iskandarani, Y. Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture. EKB Journal Management System, 2025; 4(1): 154-166. doi: 10.21608/ermhs.2025.371187.1051

Adult Bacterial Meningitis: Earlier Treatment and Improved Outcome following Guideline Revision Promoting Prompt Lumbar Puncture

Egyptian Reviews for Medical and Health Sciences
Volume 4, Issue 1, March 2025, Page 154-166  XML PDF (721.41 K)
Document Type: Original Article
DOI: 10.21608/ermhs.2025.371187.1051
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Authors
Maher Abd Elhmmed Sherif email 1; Khalid Abd Elkarim Karam2; Zakaria Moh Abd Elbaset3; Dalya Ayman Iskandarani4; Yara Ayman Iskandarani5
1Assist professor of anaesthesia and intensive care, Faculty of Medicine Alazhar University, Cairo, Egypt
2Assist professor, Radiology Consultant, Faculty of Medicine Alazhar University, Cairo, Egypt.
3Assist professor, Neuropsychiatric Consultant, Psychatric department, Faculty of Medicine Alazhar University, Cairo, Egypt
4Intern Doctor, Department of Medicine, Bahçeşehir University, Istanbul, Turkey
5Medical Doctor, King Fahad Hospital Department of Internal Medicine, Madinah, Saudi Arabia
Abstract
Abstract
Background: Acute bacterial meningitis (ABM) is a potentially fatal illness. In spite of modern therapy and intensive care, the death rate remains between ten percent and thirty percent, and the possibility of persistent neurological or auditory deficits is high.
Aim: To evaluate the outcome of lumbar puncture (LP) carried out rapidly or following neuroimaging in acute bacterial meningitis in adults
Patients and methods: This prospective investigation has been performed on 600 adult cases with acute bacterial meningitis (ABM) with age >16 years. The diagnoses of ABM have been dependent on cerebrospinal fluid analysis, clinical criteria, and blood microbiological tests. This study was done at Al-Azhar University from May 2020 to Jan 2021.
Results: A statistically insignificant distinction has been observed among lumbar puncture without before CT and lumbar puncture following CT regarding age, sex, immunocompromised state, and reaction level scale (RLS) 2–3 mental status, while there was a statistically significant lower in LP after CT when compared to LP without prior CT regarding Neisseria meningitides, RLS 1 mental status, and time from admission to appropriate therapy and a significant increase regarding Streptococcus pneumoniae and RLS 4–8 mental status.
Conclusion: CT-conducted prior lumbar puncture slows and elevates the death possibility. In instances of mass lesions or impending herniation, a CT scan must be conducted. A prompt lumbar puncture is recommended, and altered mental status, seizures, and immunocompromised states shouldn't be considered for neuroimaging in cases with suspected ABM
Keywords
Key words: ABM; LP; neuroimaging
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