Urine Cofilin-1 As An Early Predictor For Type 1 Cardio renal Syndrome in the Coronary Care Unit

Abd-el-Kader, Ahmed Mohamed Abd-el-Rahim; Ismail, Mabrouk Ibrahim; Afify, Walid; Kamal, Nafesa Mohammed; Samour, Hanan Abdelsalam Ali; Morsi, Fatima Al Taher Taha

doi:10.21608/zumj.2025.365210.3860

	Urine Cofilin-1 As An Early Predictor For Type 1 Cardio renal Syndrome in the Coronary Care Unit
Zagazig University Medical Journal
Volume 31, Issue 7, July 2025, Page 2661-2673 PDF (1.07 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2025.365210.3860
View on SCiNiTO
Authors
Ahmed Mohamed Abd-el-Rahim Abd-el-Kader ¹; Mabrouk Ibrahim Ismail²; Walid Afify²; Nafesa Mohammed Kamal²; Hanan Abdelsalam Ali Samour²; Fatima Al Taher Taha Morsi ²
¹1Internal Medicine Department, Al-Ahrar Teaching Hospital, General Organization for Teaching Hospitals and Institutes (GOTHI), Egypt
²Internal Medicine & Nephrology Department, Faculty of Medicine - Zagazig University
Abstract
Background: Patients with acute decompensated heart failure (ADHF) may experience major consequences from type 1 cardio renal syndrome (CRS), which can have a major impact on HF patients. Urine Cofilin-1 measured by the gold nanoparticle-based immunoassay LSPCFB could be used as a single biomarker for CRS prediction in patients in critical care units. So we aimed to evaluate performance of urine cofilin-1 as a predictor for type 1 Cardio renal Syndrome patients using Gold Nanoparticle- and Laser-Based Approach in coronary care unit. Methods: A case-control study was conducted on 60 subjects admitted to the Coronary Care Unit (CCU). Participants were divided into four groups based on heart and renal function status. Urine Cofilin-1 levels were measured using ELISA and LSPCFB. Patients were monitored for 7 days to confirm CRS development based on KDIGO criteria. Results: Urine Cofilin-1 levels were significantly elevated in CRS patients compared to other groups. The LSPCFB method showed superior specificity and overall diagnostic accuracy (AUC = 0.678) compared to ELISA. Correlations were observed between Cofilin-1 levels and several renal and cardiac function parameters. LSPCFB showed higher diagnostic performance, with an optimal cutoff of ≥0.3 and acceptable sensitivity (73.3%) and specificity (70%). Conclusion: Urine Cofilin-1 is a promising early biomarker for detecting Type 1 CRS, especially when measured using the LSPCFB technique.
Keywords
Heart Failure; Cardio-Renal Syndrome; type 1 urine cofilin; AKI


Statistics Article View: 8,187 PDF Download: 41