The impact of advanced maternal age on fertility outcomes in IVF cycles in Al amal IVF Center-Misrata | ||
| Journal of Reproductive Medicine and Embryology | ||
| Article 5, Volume 1, Issue 4, February 2025, Pages 235-242 PDF (466.92 K) | ||
| Document Type: Cohort and Case-Control Studies | ||
| DOI: 10.21608/jrme.2025.366530.1032 | ||
| Authors | ||
| Hussain Mohamed Asherkaci* ; Enaam Baltu; Mohamed Danfour | ||
| Al Amal IVF Center - Misrata | ||
| Abstract | ||
| ABSTRACT Backround: A delay in childbearing to later n life has increase the number of women of advance maternal age (AMA) opting for assisted reproductive, women should be made aware that age-related changes to fertility including decline in Oocyte reserve and quality in addition to increase in the number of Oocyte chromosomal aberration. Aim: To evaluate the effect of maternal age on the outcomes of in vitro fertilization (IVF) and embryo transfer (ET) in fresh and frozen embryo cycles. Method: This is a retrospective observational cohort study from a last 1000 patients aged 40-48 years in sequence without exclusion, who underwent IVF with intra-cytoplasmic sperm injection in Al Amal IVF Center – Misrata. The study assess the embryo transfer rate, clinical pregnancy and miscarriage rates. Results: The study includes last 1000 cases aged above 40 years old underwent ICSI/IMSI cycle. In fresh embryo cycle 500 cases and in frozen embryo cycle 500 cases, four groups of different maternal age periods were compared, (40-42) years old group, (42-44) years old group, (44-46) years old group and (46-48) years old group. The retrieved Oocyte number and clinical pregnancy rate were significantly lower in groups of higher maternal age, while the miscarriage rate was significantly higher in groups of good quality embryo. Conclusion: Patient with higher maternal age had low IVF outcomes and patients over 40 years old have poor IVF outcome and high miscarriage rate, clinicians should be very cautious in counseling of this age group and give the expected incidence. | ||
| Keywords | ||
| frozen embryo; in vitro fertilization; embryo transfer | ||
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