Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.
Abd El-sameaa, A., Badawy, A., Abdul Kader, N., El-Ayouty, M., ahmed, S., Zikry, S. (2025). Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.. EKB Journal Management System, 9(2), 1-7. doi: 10.21608/rpbs.2025.353708.1350
Ahmed Mohamed Abd El-sameaa; Ahmed M. Badawy; Nermeen Azmy Abdul Kader; Mayada Mohamed El-Ayouty; safwat AM ahmed; Salwa Hassan Zikry. "Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.". EKB Journal Management System, 9, 2, 2025, 1-7. doi: 10.21608/rpbs.2025.353708.1350
Abd El-sameaa, A., Badawy, A., Abdul Kader, N., El-Ayouty, M., ahmed, S., Zikry, S. (2025). 'Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.', EKB Journal Management System, 9(2), pp. 1-7. doi: 10.21608/rpbs.2025.353708.1350
Abd El-sameaa, A., Badawy, A., Abdul Kader, N., El-Ayouty, M., ahmed, S., Zikry, S. Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.. EKB Journal Management System, 2025; 9(2): 1-7. doi: 10.21608/rpbs.2025.353708.1350

Phytochemical Investigation and in vitro Antioxidant Activities of Cleome amblyocarpa Cultivated in North Sinai.

Records of Pharmaceutical and Biomedical Sciences
Volume 9, Issue 2, March 2025, Pages 1-7    PDF (625.99 K)
Document Type: Original Article
DOI: 10.21608/rpbs.2025.353708.1350
Authors
Ahmed Mohamed Abd El-sameaa* 1; Ahmed M. Badawy2; Nermeen Azmy Abdul Kader3; Mayada Mohamed El-Ayouty1; safwat AM ahmed4; Salwa Hassan Zikry5
1Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, El-Arish, Egypt,
2pharmacognosy department, faculty of pharmacy, Sinai university, Al-arish, Cairo, Egypt
3Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt
4pharmacognosy department,faculty of pharmacy,Suez canal university,Ismailia,Egypt.
5Department of Pharmacognosy, Faculty of Pharmacy, Sinai University– Arish Branch, Arish, 45511, Egypt,
Abstract
The development of new pharmaceuticals has mostly benefited from natural products. The widespread medicinal usage of species in Cleomaceae family is extensively researched. Cleome amblyocarpa Barr. and Murb. from the family Cleomaceae is a widely grown plant in Sinai Peninsula of Egypt. C. amblyocarpa is used in folk medicine as it has analgesic, anti-inflammatory, antibacterial, and antioxidant activities. in this study, the total phenolic content (TPC), total flavonoids content (TFC), and antioxidant activity of crude methanolic extract from whole parts of Cleome amblyocarpa growing in Sinai were investigated. Total phenolics and flavonoid contents of the extract were determined by the Folin–Ciocalteu and aluminum chloride methods, respectively. The total phenolic and flavonoid content of C. amblyocarpa were 15.63 ± 1.158 μg GA E/mg and 16.1 ± 0.14 µg RE/mg respectively. Two in vitro assays (FRAP, and DPPH) were used to determine the antioxidant activity and the ferric reducing ability (FRAP) by C. amblyocarpa extract was found to be (65.383 ± 3.88 μM eq/mg) in comparison with Trolox (6.414± 1.034 µg/mL). The radical scavenging activity on DPPH (IC50 values of 570.6 ± 1.045 µg/mL) was determined using Trolox as a standard drug.
Keywords
Cleome amblyocarpa; Antioxidant activity; DPPH; FRAP
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