Evaluation of arthrocentesis with and without platelet rich plasma injection in patients with disc displacement with reduction. A randomized controlled clinical trial

Alhoor, Mohammad Ibraheem; Kadry, Walaa; Nassar, Yasmine

doi:10.21608/edj.2025.341695.3289

	Evaluation of arthrocentesis with and without platelet rich plasma injection in patients with disc displacement with reduction. A randomized controlled clinical trial
Egyptian Dental Journal
Volume 71, Issue 2, April 2025, Page 1177-1188 PDF (967.3 K)
Document Type: Original Article
DOI: 10.21608/edj.2025.341695.3289
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Authors
Mohammad Ibraheem Alhoor ¹; Walaa Kadry ²; Yasmine Nassar ²
¹Principal Researcher At Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt
²Associate Professor at Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Abstract
Objectives: The current study aimed to assess the effect of arthrocentesis followed by injection of platelet rich plasma (PRP) versus arthrocentesis in the management of anterior disc displacement with reduction (DDWR) disorder. Materials and methods: Seventy-four patients ( mean age 29.3 years) with anterior DDWR were randomized and divided according to a predetermined eligiblity criteria into two equal groups: arthrocentesis (control) and arthrocentesis with PRP injection ( study).For both groups, Pain intensity was assessed using visual analogue scale and maximum mouth opening (MMO) preoperatively, immediate, 1 week, 1 month, 3 and 6 months postoperatively. Moreover, the disc displacement angle was recorded preoperative and after 6 months. Results: Pain was significantly reduced in the study group compared to the control group only at 1 week, 1 month, 3 and 6 months (p < 0.05). However, there was non significant difference among groups regarding MMO at all time intervals or disc position angle after 6 months (p>0.05). Conclusions: PRP resulted in pain reduction for most of the period of follow up, with no apparent positive effect on MMO or disc position. Clinical Relevance: The study evaluates whether the anti-inflammatory and growth stimulation effect of PRP is reflected on reduction of pain intensity and disc position in the management of patients suffering from DDWR. Clinical trial registration NCT05983653
Keywords
Platelet rich plasma; internal derangement; arthrocentesis; temporomandibular joint


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