Frequency, Clinical Characteristics, and Risk Factors of Nonalcoholic Fatty Liver Disease in Lean Individuals attending Qena University Hospital | ||
| SVU-International Journal of Medical Sciences | ||
| Article 66, Volume 8, Issue 1, January 2025, Pages 755-765 PDF (288.26 K) | ||
| Document Type: Original research articles | ||
| DOI: 10.21608/svuijm.2023.231414.1665 | ||
| Authors | ||
| Shamardan Ezzeldin Sayed Bazeed1; Ahlam Mohamed Sabra Ali2; Wafaa Mosallam Mohammed Seleem* 1; Heba Ahmed Osman Saleh1 | ||
| 1Tropical Medicine and Gastroenterology Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| 2Internal Medicine Department, Faculty of Medicine, South Valley University, Qena, Egypt | ||
| Abstract | ||
| Background: Non-alcoholic fatty liver disease (NAFLD) involves liver fat accumulation without alcohol, including NAFL and Non alcoholic steatohepatitis (NASH). Rising globally due to obesity, and diabetes, affecting even lean individuals (lean-NAFLD), demanding focused management and prevention. Objectives: To assess the frequency, clinical characteristics, and risk factors of NAFLD in lean individuals. Patients and methods: The cross-sectional study at South Valley University Hospital involved 200 lean participants with BMI within ethnic-specific cutoffs. Comprehensive assessments included history, examinations, laboratory tests, and abdominal ultrasonography. Fibroscan, Fibrosis-4 (FIB-4), and Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) scores were used to determine liver fibrosis stages and predict fibrosis and cirrhosis. Results: The study involved 200 lean participants with an average age of 40.72 ± 6.71 years, 166 (83%) non-NAFLD patients and 34 (17%) NAFLD patients. Males made up 60.2% of the non-NAFLD group and 70.6% of the NAFLD group, while females made up 39.8% of the non-NAFLD group and 29.4% of the NAFLD. Lean NAFLD was associated with increased hip circumference, altered waist-to-height ratio and arm circumference, higher Systolic and diastolic blood pressure, also higher levels of HOMA-IR, TSH, and uric acid. 6% of the NAFLD group had ASMA, AMA positive with significant elevations in fibrosis and liver stiffness measurements. Conclusion: Lean NAFLD associated to elevated lipid profile, liver enzymes, protein, HOMA-IR, blood sugar, uric acid, TSH. | ||
| Keywords | ||
| Liver; NAFLD; Obesity; Lean individuals | ||
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