Omitting Radiation in young adult females with Hodgkin’s Disease, Is there an Impact on Outcome? | ||||
| Egyptian Journal of Cancer and Biomedical Research | ||||
| Volume 9, Issue 1, March 2025, Page 51-60 PDF (839.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcbr.2025.360082.1385 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Samah FA Semary   1; Emad Ali Helmy Moussa2; Asmaa Hamoda3; Eman Nagib4; Salma Abdelaziz5; Mahmoud Hamza6; Madeha Elwakil7; Mohamed Zaghloul8
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| 1Department of oncology, Beni-Suef University, Beni-Suef, Egypt. Depaetment of pediatric oncology, Children Cancer Hospital Egypt | ||||
| 2Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Clinical Oncology, Menufiya University, Shebeen, Egypt | ||||
| 3Department of Pediatric Oncology, Children Cancer Hospital Egypt, Cairo, Egypt Department of Pediatric Oncology, National Cancer Institute/ Cairo University, Cairo, Egypt | ||||
| 4Department of Pathology/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Pathology, Children Cancer Hospital Egypt, Cairo, Egypt | ||||
| 5Department of Nuclear Medicine, Children Cancer Hospital Egypt, Cairo, Egypt Department of Nuclear Medicine, National Cancer Institute/ Cairo University, Cairo, Egypt | ||||
| 6Department of Clinical Research, Children Cancer Hospital Egypt, Cairo, Egypt | ||||
| 7Department of radiodiagnosis/ National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiodiagnosis, Children Cancer Hospital Egypt, Cairo, Egypt | ||||
| 8Department of Radiotherapy, National Cancer Institute/ Cairo University, Cairo, Egypt Department of Radiotherapy, Children Cancer Hospital Egypt, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Ionizing radiation is a breast cancer risk factor. This retrospective study aims to compare the outcome of young adolescent females diagnosed and treated with classic Hodgkin lymphoma who received chemotherapy while omitting radiotherapy for fear of the increased risk of breast cancer and those who received chemotherapy followed by radiotherapy in an attempt to explore the impact of radiotherapy on the outcome and to record the late side effects of radiotherapy as well as the incidence of breast cancer among these patients. About 166 young adolescent females between 12 and 18 years old were diagnosed and treated with classic Hodgkin lymphoma in the Children’s Cancer Hospital Egypt from July 2007 till the end of 2018, the no radiotherapy (RT) group (72 patients) received chemotherapy while omitting radiotherapy, the RT group (94 patients) received chemotherapy and radiotherapy, with 5years OS 93%, 87% respectively, and with 5years EFS 74%, 85% respectively, with P-value 0.062. The initial stage and response to treatment using interim PET CT scans post-second cycle chemotherapy were documented. The outcomes were nearly identical in the no RT and RT groups. In conclusion, omitting radiation therapy did not affect the 5-year EFS; nevertheless, the existence of positive B symptoms, an advanced stage initially, or a poor response to treatment all impacted the 5-year EFS. | ||||
| Keywords | ||||
| Hodgkin lymphoma; radiotherapy; breast cancer; advanced stage; interim PET CT | ||||
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