Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model
Helal, M., El-Sekaily, A., Shetewy, M., Soliman, H., Elnemr, A., Ghonim, H., El-Sedfy, A., Saad, A., Hassan, J. (2025). Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model. EKB Journal Management System, 9(1), 61-70. doi: 10.21608/jcbr.2025.353492.1382
Mohamed Helal; Amany El-Sekaily; Mohamed Shetewy; Hoda Soliman; Abdallah Elnemr; Hossam Ghonim; Amal El-Sedfy; Aziza Saad; Jihan Hassan. "Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model". EKB Journal Management System, 9, 1, 2025, 61-70. doi: 10.21608/jcbr.2025.353492.1382
Helal, M., El-Sekaily, A., Shetewy, M., Soliman, H., Elnemr, A., Ghonim, H., El-Sedfy, A., Saad, A., Hassan, J. (2025). 'Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model', EKB Journal Management System, 9(1), pp. 61-70. doi: 10.21608/jcbr.2025.353492.1382
Helal, M., El-Sekaily, A., Shetewy, M., Soliman, H., Elnemr, A., Ghonim, H., El-Sedfy, A., Saad, A., Hassan, J. Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model. EKB Journal Management System, 2025; 9(1): 61-70. doi: 10.21608/jcbr.2025.353492.1382

Marine algae Cystoseira indica extracted alginate alleviates toxicity and inflammation pathways in Osteoarthritis induced rat model

Egyptian Journal of Cancer and Biomedical Research
Volume 9, Issue 1, March 2025, Page 61-70  XML PDF (1000.09 K)
Document Type: Original Article
DOI: 10.21608/jcbr.2025.353492.1382
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Authors
Mohamed Helal email 1; Amany El-Sekaily2; Mohamed Shetewy3; Hoda Soliman3; Abdallah Elnemr4; Hossam Ghonim5; Amal El-Sedfy6; Aziza Saad3; Jihan Hassan3
1National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt Department of Biology, University of Southern Denmark, Odense, 5230, Denmark
2National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt
3Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt
4Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt
5Department of Immunology, Medical Research Institute, Alexandria University, Alexandria, Egypt
6Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Background: Brown algae are known for synthesizing bioac-tive compounds with anti-inflammatory properties, which have shown potential in addressing inflammation-related disorders. Osteoarthritis (OA), a joint disease characterized by significant inflammation, negatively impacts overall health and quality of life. Aim:

This study aimed to evaluate the therapeutic potential of algi-nate extracted from the brown algae Cystoseira indica in miti-gating OA using a rat model. Materials & Methods: OA was induced in rats through intra-articular administration of mono-sodium iodoacetate (MIA). The experimental design included a control group, an MIA-induced OA group, and an alginate-treated group (MIA + alginate). Samples were collected at in-tervals of 2, 4, 6, and 10 weeks to assess pro-inflammatory cy-tokine levels, biochemical markers, and histopathological changes in knee cartilage. Results

OA induction led to a significant increase in pro-inflammatory and oxidative stress markers, including malondialdehyde (MDA), interleukin 1-beta (IL1β), tumor necrosis factor-alpha (TNF-α), beta-glucuronidase (β-G), acid phosphatase (ACP), and aggrecanase 1, alongside a marked reduction in glutathi-one (GSH) levels. Alginate treatment significantly mitigated OA progression, as evidenced by reduced levels of MDA, IL1β, TNF-α, β-G, ADAMTS4, and matrix metalloproteinase-3 (MMP-3), coupled with increased GSH levels and improved cartilage recovery and regeneration. Conclusion

Alginate from C. indica demonstrates significant potential in mitigating OA through its anti-inflammatory effects, highlight-ing its promise as a therapeutic agent for inflammation-related joint disorders.
Keywords
Alginate; antioxidant; anti-inflammatory; osteoarthritis; and proinflammatory cytokines
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