Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer
Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. (2024). Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer. EKB Journal Management System, 27(6), 24-34. doi: 10.21608/scumj.2024.421503
Sara Abd EL-Monem Aboelroos; Elsayed Hussein Mostafa Eltamany; Faten Abdelmonem Metwalli Mohamed; Marwa Awad Suliman. "Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer". EKB Journal Management System, 27, 6, 2024, 24-34. doi: 10.21608/scumj.2024.421503
Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. (2024). 'Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer', EKB Journal Management System, 27(6), pp. 24-34. doi: 10.21608/scumj.2024.421503
Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer. EKB Journal Management System, 2024; 27(6): 24-34. doi: 10.21608/scumj.2024.421503

Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer

Suez Canal University Medical Journal
Article 3, Volume 27, Issue 6, June 2024, Page 24-34  XML PDF (581.74 K)
Document Type: Original Article
DOI: 10.21608/scumj.2024.421503
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Authors
Sara Abd EL-Monem Aboelroosorcid 1; Elsayed Hussein Mostafa Eltamanyorcid 2; Faten Abdelmonem Metwalli Mohamed email orcid 3; Marwa Awad Sulimanorcid 4
1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.
2Department of Organic Chemistry, Faculty of Science, Suez Canal University, Egypt.
3Department of Biochemistry, Faculty of Science, Suez Canal University, Egypt.
4Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.
Abstract
Background: the most common cancer detected in females is ‎breast ‎cancer. Several genetic alterations may have prognostic effect on ‎breast ‎cancer. Single-nucleotide polymorphisms might predict breast ‎cancer ‎management. Single nucleotide polymorphisms of PvuII ‎‎(T/C ‎substitution) and aryl hydrocarbon (G/A substitution) were ‎estimated as ‎probable genetic prognostic factors for breast cancer. Aim: ‎to assess the ‎relation between estrogen receptor alpha PvuII (rs2234693) ‎and aryl ‎hydrocarbon receptor gene polymorphisms (rs2066853) in ‎breast cancer ‎prognosis. Material and method: this study is case-control ‎that ‎enrolled 120 breast cancer patients categorized into two groups: the ‎first ‎one involved 60 females with good prognostic factors, the second ‎group ‎included 60 females with poor prognostic factors. Genotyping ‎assay ‎were done by a real-time polymerase chain reaction. Results: our ‎finding ‎revealed that the allelic frequency of wild-type genotypes for ‎PvuII and ‎AhR polymorphisms was associated with patients who had ‎better ‎prognosis for breast cancer. Their mutant genotypes were ‎significantly ‎associated with poor prognoses in breast cancer patients. ‎Conclusion: ‎PvuII, AhR genotypes were statistically significant ‎associated with ‎breast cancer ‎ prognosis. ‎
Keywords
Genetic factors; Estrogen receptor; aryl hydrocarbon; prognosis
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