Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3
AMR, A., Mostafa, R., Ghazy, S. (2025). Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3. EKB Journal Management System, 71(2), 1401-1416. doi: 10.21608/edj.2025.359006.3378
AHMED ELSAYED HAMED AMR; Raghdaa Mostafa; Shaimaa Ghazy. "Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3". EKB Journal Management System, 71, 2, 2025, 1401-1416. doi: 10.21608/edj.2025.359006.3378
AMR, A., Mostafa, R., Ghazy, S. (2025). 'Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3', EKB Journal Management System, 71(2), pp. 1401-1416. doi: 10.21608/edj.2025.359006.3378
AMR, A., Mostafa, R., Ghazy, S. Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3. EKB Journal Management System, 2025; 71(2): 1401-1416. doi: 10.21608/edj.2025.359006.3378

Randomized Controlled Clinical Study Evaluating Dental Implant Primary Stability, Radiographic Bone Density and Osteopontin Expression in the Regenerated Alveolar Bone in Post-Extraction Sockets Treated with Vitamin D3

Egyptian Dental Journal
Volume 71, Issue 2 - Serial Number 3, April 2025, Page 1401-1416  XML PDF (2.53 MB)
Document Type: Original Article
DOI: 10.21608/edj.2025.359006.3378
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Authors
AHMED ELSAYED HAMED AMR email orcid 1; Raghdaa Mostafaorcid 2; Shaimaa Ghazyorcid 3
1Associate Professor of Oral Medicine and Periodontology, Faculty of Dentistry, Ain Shams University
2Associate Professor of Oral and Maxillofacial Radiology, Faculty of Dentistry, Ain Shams University
3Associate Professor of Oral Pathology, Faculty of Dentistry, Ain Shams University
Abstract
Purpose of the study: Evaluating the influence of combination of vitamin D3 with particulate bovine xenograft when placed in post-extraction sockets on the newly formed bone quality.
Primary outcome: Implant primary stability
Secondary outcomes: Radiographic bone density and immunohistochemical expression of osteopontin in newly formed regenerated bone
Subjects and methods: Patient with non-restorable maxillary anterior tooth or single root premolar that require extraction and dental implant. Test group: 13 extraction sites received particulate xenograft mixed with vitamin D3. Control group: 13 extraction sites received particulate xenograft alone. After 6 months implants were placed. Implant primary stability, radiographic bone density, immunohistochemical osteopontin expression in grafted sites were evaluated.
Results: A significantly higher mean value of both primary stability and bone density were recorded in test group.
Conclusion:
Taking in considerations the limitations of the current study, the addition of vitamin D to particulate xenogenic bone graft enhanced newly formed bone density, implant stability and is associated with increased expression of OPN level in grafted sites.
Keywords
Tooth Socket; Vitamin D; augmentation
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