Antibiotics susceptibility testing of meropenem-resistant bacteria isolated from pigs from selected farms in Ado Ekiti, Nigeria | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 10 April 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.363278.2576 | ||
| Authors | ||
| Olajumoke kemi Ekundayo* ; Isaac Iseoluwa Ajayi | ||
| Bamidele Olumilua University of Education Science and Technology, Ikere-Ekiti, NIgeria | ||
| Abstract | ||
| Background: Antimicrobial resistance (AMR) is a major global health concern, especially with the emergence of carbapenem-resistant Enterobacteriaceae (CRE). This work investigates the antibiotic susceptibility testing (AST) of meropenem-resistant bacteria isolated from pig farms in Ado Ekiti, Nigeria. Method: A cross-sectional study design was used, with samples obtained from 90 pigs on three farms. The bacterial isolates were cultured, identified using genetic techniques, and those resistant to meropenem. 10µg were tested for antibiotic susceptibility testing with fosfomycin, nitrofurantoin, tigecycline, gentamicin, and polymyxin B. The study identified significant bacterial species such as Escherichia coli, Proteus mirabilis, Providencia alcalifaciens, Shigella flexneri, Enterococcus faecalis, and Bacillus cereus Results: Meropenem-resistant bacterial isolates were susceptible to some considered ancient antibiotics such as fosfomycin, nitrofurantoin, tigecycline, and gentamicin, with sensitivity percentages of 92.86%, 85.71%, 92.86%, and 92.86%, respectively. Polymyxin B had the lowest effectiveness, with a sensitivity of 64.23%. The study focuses on meropenem resistance in pigs, raising concerns about their role as reservoirs for antimicrobial-resistant bacteria. Conclusion: The findings highlight the outcome of the research, which suggested that fosfomycin, nitrofurantoin, tigecycline, and gentamicin can be used to treat meropenem-resistant bacteria isolated from pigs. It should be noted that there is the possibility of spreading resistant germs to humans through direct contact, environmental contamination, or the food chain. This study underlines the importance of considering “sold” antibiotics for treatment, complete antimicrobial stewardship programs, the prudent use of antibiotics in veterinary practices, and improved biosecurity measures in animal husbandry | ||
| Keywords | ||
| Antibiotics; pig; animal | ||
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