ACOMPARATIVE EVALUATION OF THE EFFICACY OF MELATONIN GEL AND CHLORHEXIDINE GEL ON TRAUMATIC TONGUE ULCER IN RATS | ||
| Alexandria Dental Journal | ||
| Articles in Press, Corrected Proof, Available Online from 11 April 2025 PDF (961.81 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/adjalexu.2025.332216.1550 | ||
| Authors | ||
| Yasmine El Fakharany* 1; Fatma Amin Adam1; Eglal Moussa1; Aya Sayed Sedik2; Asmaa Ashour3 | ||
| 1Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Egypt | ||
| 2Department of Oral Biology, Faculty of Dentistry, Alexandria University, Alexandria, Egypt | ||
| 3Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University 21521, Egypt. | ||
| Abstract | ||
| INTRODUCTION: Wound healing is a complex process accomplished through predetermined phases. Chlorhexidine digluconate has an effect on oral tissue repair. Furthermore, it is well known that melatonin has antioxidant and anti-inflammatory properties. OBJECTIVES: To compare the efficacy of melatonin gel and chlorhexidine gel on traumatic tongue ulcer in rats. MATERIALS AND METHODS: Three groups of fifty-four male rats were created: Group І (negative control) (n=18); Group Ⅱ (melatonin group) (n=18); and Group Ⅲ (chlorhexidine group) (n=18). A biopsy punch size of 3.5mm was used to induce an oral wound at the dorsal surface of the tongue in all groups. Afterwards, Group І received no treatment, Group Ⅱ received (5mg ̸ kg ̸ day) of melatonin gel, and Group Ⅲ received (10mg once daily) of chlorhexidine gel for 9 days. Then, the rats were euthanized at (3rd, 7th, and 9th days), and the lingual mucosa was dissected out and evaluated using a light microscope, immunohistochemically, and a scanning electron microscope. RESULTS: Histological examination of the chlorhexidine group and melatonin group showed improved ulcer healing in comparison to the control group. The immunohistochemical findings of the chlorhexidine and melatonin groups showed strong positive reactivity to (α SMA). CONCLUSIONS: A significant effect of topical application of chlorhexidine gel on accelerating and improving wound healing in traumatic tongue ulcer in rats, while melatonin can be used as a natural substitute in oral wound healing. | ||
| Keywords | ||
| Wound healing; melatonin; chlorhexidine; α smooth muscle actin (α-SMA) | ||
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