Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing | ||
| Egyptian Journal of Physical Therapy and Rehabilitation | ||
| Articles in Press, Accepted Manuscript, Available Online from 16 April 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejptr.2025.374539.1024 | ||
| Authors | ||
| Fatma Helmy Elmlegy* 1; Walied Mohamed Khereba2; Shaimaa M. A. Elsayeh3; Hesham Galal Mahran3 | ||
| 1Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Delta University for Science and Technology, Egypt. | ||
| 2Department of Vascular and Endovascular Surgery, Faculty of Medicine, Al-Azhar University-New Damietta. | ||
| 3Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University. | ||
| Abstract | ||
| Background: Venous ulcers are chronic open skin lesions resulting from venous hypertension. When conservative treatments fail, alternative approaches are necessary. Purpose: This study aimed to evaluate the effectiveness of ultrasound-enhanced hyaluronic acid delivery (phonophoresis) for venous ulcer healing. Materials and methods: Sixty-four venous ulcer patients participated in this randomized clinical trial. Participants were equally divided into two groups. Group A received a combination of topical hyaluronic acid gel and ultrasound therapy, while Group B received ultrasound followed by topical hyaluronic acid. Wound surface area was measured before and after four weeks of treatment. Results: Group A showed a highly significant reduction in wound surface area (51.15%) compared to Group B (31.02%) (p = 0.001). Conclusion: The study concluded that the combination of hyaluronic acid and ultrasound therapy via phonophoresis is more effective in venous ulcer healing than sequential treatment. This method provides a promising adjunct to traditional therapies for venous ulcer management. | ||
| Keywords | ||
| Therapeutic ultrasound; hyaluronic Acid; phonophoresis; Ulcer; wound Healing | ||
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