Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing
Elmlegy, F., Khereba, W., A. Elsayeh, S., Mahran, H. (2025). Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing. EKB Journal Management System, (), -. doi: 10.21608/ejptr.2025.374539.1024
Fatma Helmy Elmlegy; Walied Mohamed Khereba; Shaimaa M. A. Elsayeh; Hesham Galal Mahran. "Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejptr.2025.374539.1024
Elmlegy, F., Khereba, W., A. Elsayeh, S., Mahran, H. (2025). 'Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing', EKB Journal Management System, (), pp. -. doi: 10.21608/ejptr.2025.374539.1024
Elmlegy, F., Khereba, W., A. Elsayeh, S., Mahran, H. Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejptr.2025.374539.1024

Effect of Ultrasound-Enhanced Hyaluronic Acid on Venous Ulcer Healing

Egyptian Journal of Physical Therapy and Rehabilitation
Articles in Press, Accepted Manuscript, Available Online from 16 April 2025  XML
Document Type: Original Article
DOI: 10.21608/ejptr.2025.374539.1024
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Authors
Fatma Helmy Elmlegy email 1; Walied Mohamed Khereba2; Shaimaa M. A. Elsayeh3; Hesham Galal Mahran3
1Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Delta University for Science and Technology, Egypt.
2Department of Vascular and Endovascular Surgery, Faculty of Medicine, Al-Azhar University-New Damietta.
3Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University.
Abstract
Background: Venous ulcers are chronic open skin lesions resulting from venous hypertension. When conservative treatments fail, alternative approaches are necessary.
Purpose: This study aimed to evaluate the effectiveness of ultrasound-enhanced hyaluronic acid delivery (phonophoresis) for venous ulcer healing.
Materials and methods: Sixty-four venous ulcer patients participated in this randomized clinical trial. Participants were equally divided into two groups. Group A received a combination of topical hyaluronic acid gel and ultrasound therapy, while Group B received ultrasound followed by topical hyaluronic acid. Wound surface area was measured before and after four weeks of treatment.
Results: Group A showed a highly significant reduction in wound surface area (51.15%) compared to Group B (31.02%) (p = 0.001).
Conclusion: The study concluded that the combination of hyaluronic acid and ultrasound therapy via phonophoresis is more effective in venous ulcer healing than sequential treatment. This method provides a promising adjunct to traditional therapies for venous ulcer management.
Keywords
Therapeutic ultrasound; hyaluronic Acid; phonophoresis; Ulcer; wound Healing
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