Insights into Programmed Cell Death: Morphology, Mechanisms, and Its Role in Disease Progression | ||
| Egyptian Journal of Histology | ||
| Articles in Press, Accepted Manuscript, Available Online from 18 April 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/ejh.2025.351671.2196 | ||
| Authors | ||
| eman faruk* 1; ahmed zazaa2; aisha Elmansy3; neama mohamoud4 | ||
| 11Department of Histology and Cytology, Faculty of Medicine, Benha University, Benha, Egypt 2 Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, Saudi Arabia | ||
| 23Student at Faculty of Medicine, Benha National University, Benha Colleges in Cairo, Main Axis of El-Obour City, Egypt | ||
| 31Department of Histology and Cytology, Faculty of Medicine, Benha University, Benha, Egypt | ||
| 4Physiology Department, Umm Al-Qura University, KSA | ||
| Abstract | ||
| Programmed Cell Death (PCD) is essential for preserving cellular equilibrium and organismal health. This review explores various aspects of PCD; However, a more systematic classification of the various cell death pathways is lacking. The Morphological Categorization of PCD section delves into the structural characteristics that distinguish different types of cell death. The molecular pathways section provides an in-depth analysis of the specific biochemical processes involved in other forms of PCD, such as apoptosis and autophagy. The techniques for detecting PCD discuss current methods used to identify and study cell death, including microscopy and molecular assays. Finally, the review highlights emerging cell death pathways and their potential roles in disease development, emphasizing the importance of understanding these new mechanisms for therapeutic advancements. Furthermore, PCD plays a vital role in regulating the balance of cell survival and death, maintaining homeostasis in the body. The study of cell death pathways is recognized increasingly as a crucial target for drug maturity. Many aspects of cell death remain unclear, with some pathways poorly understood and ongoing scientific debate. Further research is needed to clarify these mechanisms, as understanding PCD regulation is crucial for health and medical advancements. Future studies should focus on uncovering complex PCD processes, aiding targeted therapies for diseases like cancer and neurodegeneration. Improved detection methods will enhance monitoring and control, leading to better treatments and patient outcomes.Cell death is a common biological process important for body growth and essential for development, linked to the onset, and progression of various diseases, and in the life cycle of an organism, tissue homeostasis, and the removal of damaged or harmful cells. It occurs in two main forms: accidental cell death (ACD) and programmed cell death (PCD). | ||
| Keywords | ||
| Programmed Cell Death (PCD); Cellular balance; Organismal health; Morphological Categorization; Structural characteristics | ||
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