Antibacterial Effect of Hyaluronic Acid Compared to Propylene Glycol as Vehicle for Double Antibiotic paste Against Bacterial Strains in Non-Vital Primary Molar (In Vitro Study) | ||||
| Ain Shams Dental Journal | ||||
| Volume 37, Issue 1, March 2025, Page 232-240 PDF (1.35 MB) | ||||
| Document Type: Original articles | ||||
| DOI: 10.21608/asdj.2024.304940.1379 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Radwa abd el aziz el shakhs   1; Amira Saad Badran 2; Nagwa Mohammed Ali Khattab 3
| ||||
| 1Egyptian Russian University | ||||
| 2Pediatric Dentistry and Dental Public Health Departement, Faculty of Dentistry, Ain Shams University | ||||
| 3Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Aim: This study aimed to evaluate the antibacterial effect of hyaluronic acid versus propylene glycol as a vehicle with double antibiotic (ciprofloxacin and metronidazole) paste against bacterial strains commonly found in non-vital primary molar roots using agar diffusion method. Materials and Methods: bacterial swap was taken using a sterile paper point size 20 from a non-vital root canal of a lower second primary molar to isolate the most common bacterial strains (staph aureus and Enterococcus faecalis) found in the root canal, The two bacterial strains were cultured in Brain Heart Infusion (BHI) broth to be used in the agar inhibition test. Subsequently, a sterile cork borer was used to aseptically create a hole with a diameter ranging from 6 to 8 mm. Then, a volume of the double antibiotic paste ciprodiazole (consisting of ciprofloxacin 500mg and metronidazole 500mg) combined with various vehicles to get the necessary creamy consistency was inserted into the hole. Inhibition zone formed around the well was measured (diameter) and recorded in millimeters using calipers and mean values were calculated. Results: For Staphylococcus aureus, values of inhibition zones formed with hyaluronic acid vehicle were significantly higher than those of propylene glycol (p<0.001). However, for Enterococcus faecalis, the difference was not statistically significant(p=0.280). Conclusions: Using hyaluronic acid as a vehicle with metronidazole and ciprofloxacin could be a good safe substitute for propylene glycol with better antibacterial effect on necrotic root canal bacterial strains. | ||||
| Keywords | ||||
| Keywords: Hyaluronic acid; Nonvital primary molars; Antibacterial effect; Double antibiotic; Propylene glycol | ||||
|
Statistics Article View: 224 PDF Download: 179 |
||||
