The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience
Hassan Hussein Hamad, M., Salih Abdallah Haroun, A., Mahjoub Taha, M., Daffalla-Awadalla Gismalla, M., Alghamdi, A., Abdalazim Abdalrahim Ahmed, M., Obeid, I., Awad, S. (2025). The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience. EKB Journal Management System, 16(2), 100-106. doi: 10.21608/ejhc.2025.423603
Mohammed Hassan Hussein Hamad; Ahmad Salih Abdallah Haroun; Mussab Mahjoub Taha; Mohamed Daffalla-Awadalla Gismalla; Abdulmajeed Alghamdi; Meysaa Abdalazim Abdalrahim Ahmed; Isam Obeid; Sami Mahjoub Awad. "The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience". EKB Journal Management System, 16, 2, 2025, 100-106. doi: 10.21608/ejhc.2025.423603
Hassan Hussein Hamad, M., Salih Abdallah Haroun, A., Mahjoub Taha, M., Daffalla-Awadalla Gismalla, M., Alghamdi, A., Abdalazim Abdalrahim Ahmed, M., Obeid, I., Awad, S. (2025). 'The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience', EKB Journal Management System, 16(2), pp. 100-106. doi: 10.21608/ejhc.2025.423603
Hassan Hussein Hamad, M., Salih Abdallah Haroun, A., Mahjoub Taha, M., Daffalla-Awadalla Gismalla, M., Alghamdi, A., Abdalazim Abdalrahim Ahmed, M., Obeid, I., Awad, S. The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience. EKB Journal Management System, 2025; 16(2): 100-106. doi: 10.21608/ejhc.2025.423603

The Impact of Varicocele Microsurgical Ligation on The Testicular Hormonal Cells: Sub-Saharan Country Experience

Egyptian Journal of Health Care
Volume 16, Issue 2, June 2025, Page 100-106  XML PDF (189.34 K)
Document Type: Original Article
DOI: 10.21608/ejhc.2025.423603
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Authors
Mohammed Hassan Hussein Hamad1; Ahmad Salih Abdallah Haroun2; Mussab Mahjoub Taha3; Mohamed Daffalla-Awadalla Gismalla4; Abdulmajeed Alghamdi5; Meysaa Abdalazim Abdalrahim Ahmed5; Isam Obeid6; Sami Mahjoub Awad email 7
1Urology specialist, Ministry of Health, Khartoum, Sudan.
2Department of Surgery, Faculty of Medicine, Omdurman Islamic University, Omdurman, Sudan
3Gezira Hospital For Renal Disease and Surgery, Ministry of Health, Wad Medani, Sudan
4Department of Surgery, Faculty of Medicine, University of Gezira, Wad Medani, Sudan and Department of Surgery, Faculty of Medicine, Al-Baha University, Al Baha, Saudi Arabia
5Department of Surgery, Faculty of Medicine, Al-Baha University, Al Baha, Saudi Arabia
6Kuwaiti Specialized Hospital, Khartoum, Sudan The medical city for military and security services (MCMSS), Muscat, Sultanate of Oman
7Professor of Urology, Unit of Urology, Department of Surgery, University of Gezira Faculty of Medicine, Medani, Sudan.
Abstract
Background: Varicocele is one of the most common causes of infertility. Various modalities, such as retrograde blood flow accumulation of metabolites and the disturbance of thermoregulation in the testicles, mediate it. This study aimed to evaluate the effect of varicocele on hormonal cells (Sertoli and Leydig cells) by measuring the semen parameters and hormones before and after microsurgical varicocele ligation. Methods: A cross-sectional study was conducted among patients who underwent microsurgical subinguinal varicocele ligation from January 2023 to December 2023 at Gezira Hospital for Renal Disease and Urology (GHRDS). Any patient with abnormal semen analysis, grade-II or grade-III varicocele (palpable or visible) with reflux who underwent microscopic sub-inguinal varicocele ligation was included in this study. Results: The sample size was 54 patients.  The mean age of them was 36±7 years. Most of the patients had left-sided and grade-III varicocele (n=42; 78%). The degree of reflux was severe in most cases (n=25; 46%). The semen parameters including count, motility, and morphology were improved postoperatively (P=0.031). There was a significant increase in testosterone levels postoperatively (pre= 3.6±1.6 ng/ml V post= 5±1.9 ng/ml, mean difference= 1.4 ng/ml; P= 0.001) and decreasing in FSH levels postoperatively (pre= 17±15 mlu/ml V post= 13.6±12.1mlu/ml, mean difference= 3.4 mlu/ml; P= 0.000). Conclusion: Varicocele had an obvious effect on hormonal cells, confirmed by the good outcomes following microsurgical varicocele ligation, which led to an increased level of testosterone, reduction of FSH, and improvement of semen parameters.
Keywords
Varicocele; microsurgical ligation; testicular hormonal cells
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