Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants
Mohamed, M., Ezzat, A., Assar, E., ismail, Y., Shehab, M. (2025). Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants. EKB Journal Management System, 42(7), 880-889. doi: 10.21608/bmfj.2025.351179.2312
Mona Hassan Mohamed; Ahmed Mahmoud Ezzat; Effat Hussein Assar; yasser mahmoud ismail; Mohamed Mahmoud Shehab. "Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants". EKB Journal Management System, 42, 7, 2025, 880-889. doi: 10.21608/bmfj.2025.351179.2312
Mohamed, M., Ezzat, A., Assar, E., ismail, Y., Shehab, M. (2025). 'Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants', EKB Journal Management System, 42(7), pp. 880-889. doi: 10.21608/bmfj.2025.351179.2312
Mohamed, M., Ezzat, A., Assar, E., ismail, Y., Shehab, M. Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants. EKB Journal Management System, 2025; 42(7): 880-889. doi: 10.21608/bmfj.2025.351179.2312

Association between Duration of Early Empiric Antibiotics and Necrotizing Enterocolitis and Late-Onset Sepsis in Preterm Infants

Benha Medical Journal
Volume 42, Issue 7, July 2025, Page 880-889  XML PDF (813.66 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.351179.2312
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Authors
Mona Hassan Mohamed email 1; Ahmed Mahmoud Ezzat2; Effat Hussein Assar2; yasser mahmoud ismail3; Mohamed Mahmoud Shehab4
1(MSc of Pediatrics, Faculty of Medicine, Benha University)
2Professor of Pediatrics, Faculty of Medicine, Benha University
3Professor of Clinical Pathology, Faculty of Medicine, Benha University
4Assistant Proffesor of Pediatrics, Faculty of Medicine, Zagazig University
Abstract
Background: Early empiric antibiotic exposure (EEAE) is a common practice in neonatal intensive care units (NICUs) to prevent infections in preterm infants. However, concerns have arisen regarding its potential association with adverse outcomes, including necrotizing enterocolitis (NEC) and late-onset sepsis (LOS). This study aims to evaluate the relationship between EEAE and the incidence of NEC and LOS in preterm infants. Methods: A comparative cross-sectional study was conducted involving 48 preterm neonates admitted to the NICU from January to August 2024. Participants were divided into two groups based on the duration of EAE: Group I those receiving prolonged antibiotics (>7days)and GroupII those receiving short-term antibiotics(
Keywords
Necrotizing Enterocolitis; Late-Onset Sepsis; Preterm Infants; Early Empiric Antibiotic Exposure
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