Effect of Bisphenol A on Nephrotoxicity in Rats and The protective Role of Giloy and Echinacea Against This Effect | ||||
| Egyptian Journal of Nutrition | ||||
| Volume 40, Issue 1, March 2025, Page 119-140 PDF (1.35 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/enj.2025.373830.1106 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
asmaa temraz  ; suzan saad; suzan samiibraheim
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| Nutrition and Food Science Department, Faculty of Home Economics, Al-Azhar University Tanta, Egypt. | ||||
| Abstract | ||||
| The BPA present in the polycarbonate plastics and epoxy resins moves from the packaging material to the dairy products eventually and caused toxicity .So that; this study aimed to investigate the potential protective effect of Giloy (Tinospora cordifolia) (T. cordifolia) and Echinacea (Echinacea purpurea ;E. purpurea), on nephrotoxicity in experimental rats. Thirty six male albino rats (50±10 g) were randomly assigned to 6 equal groups (6 rats each), the first kept as as a negative control group (-v) control received basal diet throughout the experimental period . While second was positive control group (+v) control which treated orally with BPA (25 mg/kg/day) dissolved in olive oil, to induce nephrotoxicity once daily, for 6 weeks while the four others groups fed on basal diet and treated orally with BPA (25 mg/kg/day) and ethanolic extracts of T. cordifolia (200, 400 mg/kg/day) and E. purpurea (200, 400mg/kg/day) for 6 weeks ( as a protective experiment ) . At the end of experimental period, biological evaluation, serum antioxidant enzymes, kidney function, Na, K were evaluated and MDA were estimated. Also histological changes of kidney tissues were examined. The obtained results concluded that supplemented diets with plant materials (extract of T. cordifolia and E. purpurea) improved antioxidant enzymes status, kidney function, Na, K and MDA. The best results found in high doses of T. cordifolia and E. purpurea followed by low doses of T. cordifolia and E. purpurea. So, these plants could be used for improves nephrotoxicity and may be other kidney functions. | ||||
| Keywords | ||||
| Bisphenol A; nephrotoxicity; Giloy; Echinacea | ||||
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