Evaluation of plasminogen activator inhibitor 1 as a potential biomarker of prethrombotic state in obesity | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 27 April 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.375925.1934 | ||
| Authors | ||
| Christine Hany Georgy* 1; Ashraf M M. Osman2; Hend M Moness3; Doaa Elzaeem Ismail4; Asmaa khalf kamel5 | ||
| 1Clinical pathology department, Minia university | ||
| 2Clinical Pathology, Faculty of Medicine , Minia University | ||
| 3Clinical Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt | ||
| 4Clinical Pathology Department , Faculty of Medicine , Minia University ,Egypt | ||
| 5Clinical pathology department, Faculty of medicine, Minia University | ||
| Abstract | ||
| Background Obesity is a complex metabolic disorder associated with a prothrombotic state, increasing the risk of cardiovascular diseases. Plasminogen Activator Inhibitor-1 (PAI-1) plays a key role in inhibiting fibrinolysis, leading to impaired clot breakdown and contributing to thrombotic risk. Aim This study aims to evaluate the serum levels of PAI-1 in obese individuals and assess their correlation with obesity severity according to degree of body mass index (BMI) and thrombotic markers. Methods The present study was carried out at the Clinical Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt, it was conducted on 90 subjects. The study included 60 obese patients (BMI > 30) divided into two subgroups: Group Ia (BMI > 35) and Group Ib (BMI < 35), and 30 healthy subjects with matched age and sex. Laboratory investigations included complete blood count, coagulation parameters (INR, APTT, D-dimer), and serum levels of PAI-1 measured by ELISA. Results Obese patients showed significantly higher levels of PAI-1 compared to controls (p < 0.05). A positive correlation was found between PAI-1 and BMI (r = 0.396, p < 0.05). Additionally, PAI-1 levels were positively correlated with platelet count (r = 0.327, p = 0.011), suggesting a potential link between obesity and a prethrombotic state. Conclusion This study highlights the association between obesity and increased thrombotic risk, as indicated by elevated levels of PAI-1. These findings suggest that PAI-1 could serve as a potential biomarker for prethrombotic states in obese individuals, emphasizing its role in assessing thrombotic risk in this population. | ||
| Keywords | ||
| Plasminogen Activator Inhibitor-1; Thrombosis; Obesity; ELISA | ||
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