IMMUNOHISTOCHEMICAL ASSESSMENT OF VARIOUS CONCENTRATIONS OF TOPICAL VITAMIN C SOLUTION ON CUTANEOUS WOUND HEALING IN RABBITS | ||||
| Assiut Veterinary Medical Journal | ||||
| Volume 71, Issue 185, April 2025, Page 491-501 PDF (787.4 K) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.336860.1474 | ||||
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| Authors | ||||
NOOR A. SULAIMAN  1; MOHAMMED NOMAN OMAR 2
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| 1Oral and Maxillofacial Surgery, College of Dentistry, Mosul University, Mosul , Iraq | ||||
| 2Ministry of Health-kirkuk Health Directorate, kirkuk. Iraq | ||||
| Abstract | ||||
| Vitamin C, a water-soluble antioxidant, is important in almost every phase of wound healing. However, oral routes provide some obstacles to delivering vitamin C to the skin, such as absorption limits and issues in achieving adequate bioavailability. Consequently, the current study aimed to evaluate the effectiveness of various dosages of topically applied vitamin C solution on intentional skin wound healing. 18 male albino rabbits were divided into three groups according to the time of euthanasia. Each rabbit had four full-thickness excisional skin wounds on its dorsum; one was left untreated, the second had ultrasound gel applied to it, the third had 5% topical vitamin C, and the fourth had 10% vitamin C (both covered by ultrasound gel). The animals were euthanized after 24 hours, 3 days and 7 days and MMP-9 was used for immunohistochemical analysis. The group that received 10% vitamin C had significant increases in MMP-9 expression on the first and fifth days, while the control group and the ultrasonic gel group both displayed a moderate increase. According to the study, using vitamin C topically accelerates the healing of skin wounds; higher concentrations (10%) have more beneficial effects. | ||||
| Keywords | ||||
| Vitamin C; ascorbic acid; skin wound healing; Immunohistochemistry; MMP-9 | ||||
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