Distinct oncological severity in CRC patients with obese and L-MAFLD | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 29 April 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2025.373342.1930 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Alaa M Mostafa 1; Magdy Fouad1; Afnan Nasr  1; Ahmed Mahrous Sayed2; Ahmad Mostafa3
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| 1Department of Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt | ||||
| 2Depatment of Diagnostic and Interventional radiology Minia Oncology Center, Minia, Egypt | ||||
| 3Clinical Oncology and Nuclear Medicine Department ,Faculty of medicine , Minia University. | ||||
| Abstract | ||||
| Abstract: Background: Metabolic-associated fatty liver disease MAFLD is widely acknowledged as a risk factor for colorectal cancer CRC due to the shared metabolic risk factors, obesity, and insulin resistance. Limited data about the potential effects of lean MAFLD (L-MAFLD) phenotype on clinical outcomes and tumor behavior in individuals with colorectal cancer. Aim of the study:This study aims to compare the histological and tumor characteristics of colorectal cancer patients with obese and L-MAFLD. Patients and Methods: A cross-sectional study was conducted on 73 CRC patients fulling MAFLD (imaging and metabolic risk factor), stratified into lean (n 12) and obese (n 61) groups. Results: Despite the metabolic aggressiveness of obese MAFLD than Lean counterparts, L-MAFLD patients exhibited more aggressive histological features, including severe hepatic steatosis and infiltrative tumor type (25% vs. 4.9%, p 0.02). obese MAFLD showed more moderate to poor tumor differentiation and lymph node involvement than L-MAFLD (p <0.001, 0.02 respectively) | ||||
| Keywords | ||||
| Colorectal cancer; MAFLD; lean MAFLD; obesity | ||||
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