Study of serum Fetuin-A in type 2 diabetic nephropathy with and without dialysis. | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 29 April 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2025.359622.1929 | ||||
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| Authors | ||||
Mahmoud Saad Abdelalem1; Atef Farouk Alakad2; Ali Mohammad Ali  3
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| 1Department of internal medicine , faculty of medicine , minia university | ||||
| 2Department of internal medicine ,faculty of medicine , minia university | ||||
| 3Department of internal medicine, faculty of medicine Minia University | ||||
| Abstract | ||||
| Background: Liver cells produce the glycoprotein fetuin-A, which is released into the bloodstream in large quantities. Because fetuin-A binds to the insulin receptor tyrosine kinase in muscle & fat, it causes insulin resistance in these tissues. Aim: To assess the association among plasma fetuin A & type2 diabetes mellitus, whether or not there are microvascular complications (like diabetic nephropathy), & to comprehend how fetuin-A functions as a calcification inhibitor in the pathophysiology of diabetic nephropathy. Patients & methods: This research had been retrospective cross-sectional research that was performed in the El Minia University Hospital over 80 cases separated into three groups: Group A: thirty studied cases have type2 diabetes mellitus with diabetic nephropathy (on hemodialysis). Group B: thirty studied cases have type2 diabetes with diabetic nephropathy (not on hemodialysis) and Group C: 20 healthy control subjects. Results: There had been a statistically significant difference among the studied groups regarding the mean arterial pressure after operation. The sensitivity of using Fetuin-A to predict diabetes was 48.3percent, specificity was 100percent, positive predictive value had been 100percent, negative predictive value had been 39.20% & accuracy was 61.3% Conclusion: Fetuin A levels are associated with insulin resistance, dyslipidemia, & vascular complications commonly seen in DN. Higher fetuin-A levels in dialysis studied cases reflect advanced kidney dysfunction. Fetuin-A's potential as a marker for disease severity and progression in DN is evident | ||||
| Keywords | ||||
| Fetuin-A; Type2 diabetes mellitus; diabetic nephropathy | ||||
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