EFFECT OF PROBIOTICS IN MICE EXPERIMENTALLY INFECTED WITH CRYPTOSPORIDIOSIS AND ITS RELATION TO COLON CANCER | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 5, Volume 55, Issue 1, April 2025, Page 27-36 PDF (664.96 K) | ||||
| DOI: 10.21608/jesp.2025.424998 | ||||
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| Authors | ||||
| HEND A. MOHAMED1; EMAN M. HUSSEIN1; SAHAR K. ABDELGAWAD2; SHERINE M. ELZAGAWY1; SAMER M. GAD1 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 2Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Probiotics are live microorganisms that offer health benefits. This study evaluated the crypto sporidiosis parasitic burden in experimentally infected mice received probiotics and its poten tial link to cancer. A total of six groups were included: Four were cryptosporidiosis-infected mice (30 mice each) and two control groups (10 mice each). The infected groups were immu nocompetent mice without probiotics (G1), or with probiotics (G2), and immunocompro omised mice without probiotics (G3) or with probiotics (G4). Cryptosporidiosis was diagnosed weeks 2 to 14 post-infection. The results showed that in G1, medium parasitic burden was 50% at week 2 and gradually declined to 0% by week 10, but heavy burden started at 33.4% in week 2 and dropped to 0% by week 4. In G2, medium burden decreased from 50% at week 4 to 33.4% by week 14, whereas heavy burden, which began at 50% in week 2, peaked at 66.6% by week 14, with significant difference between them. For G3, medium burden was 66.6% at week 2 and declined to 50% by week 14, but heavy burden increased from 33.4% at week 2 to 50% at week 14. In G4, med ium burden fluctuated, decreased from 16.7% at week 2 to 33.4% at week 14, but heavy burden declined from 83.3% at week 2 to 66.6% at week 14. However, the changes were insignificant. Regarding dysplastic changes, no dysplasia was observed in G1. In G2, four out of five (80%) dysplastic mice had a heavy parasitic burden. In G3, 66.6% (4/6) of dysplastic mice exhibited a heavy burden, but in G4, 78.6% (11/14) of dysplastic mice had a heavy burden, without signifi cant differences | ||||
| Keywords | ||||
| Probiotics; Cryptosporidiosis; Experimental mice; Treatment | ||||
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