Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats
Mansour, D., Morsi, R., Mansour, H., Mater, S., Essam, H., Mousa, S., El-Sayed, E. (2025). Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats. EKB Journal Management System, 68(12), 203-211. doi: 10.21608/ejchem.2025.360482.11315
Doaa S. Mansour; Reham M. Morsi; Hoda A. Mansour; Salwa N.A. Mater; H. M. Essam; Shaimaa A. Mousa; El-Sayed R. El-Sayed. "Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats". EKB Journal Management System, 68, 12, 2025, 203-211. doi: 10.21608/ejchem.2025.360482.11315
Mansour, D., Morsi, R., Mansour, H., Mater, S., Essam, H., Mousa, S., El-Sayed, E. (2025). 'Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats', EKB Journal Management System, 68(12), pp. 203-211. doi: 10.21608/ejchem.2025.360482.11315
Mansour, D., Morsi, R., Mansour, H., Mater, S., Essam, H., Mousa, S., El-Sayed, E. Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats. EKB Journal Management System, 2025; 68(12): 203-211. doi: 10.21608/ejchem.2025.360482.11315

Anti-ulcer Potential of Myco-fabricated Copper Oxide and Ferric Oxide Nanoparticles Against Ethanol Induced Gastric Ulcers in Male Albino Rats

Egyptian Journal of Chemistry
Article 18, Volume 68, Issue 12, December 2025, Page 203-211  XML PDF (1.21 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2025.360482.11315
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Authors
Doaa S. Mansour1; Reham M. Morsi1; Hoda A. Mansour1; Salwa N.A. Mater1; H. M. Essam1, 2; Shaimaa A. Mousa3; El-Sayed R. El-Sayed email orcid 3
1Biological Application Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.
2Biological Application Department, Cyclotron facility, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.
3Plant Research Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt.
Abstract
Gastric ulcers are a prevalent stomach disease that requires timely medical attention and appropriate treatment to prevent complications. In this study, the protective effects of myco-fabricated copper oxide nanoparticles (CuO-NPs) and ferric oxide nanoparticles (Fe3O4-NPs) against ethanol-induced acute gastric ulcers in rats were assessed. The rats were administered ethanol via gavage to create an acute gastric ulcer model, after which serum and stomach tissue samples were collected for biochemical analysis. The results indicated that pretreatment with CuO-NPs and Fe3O4-NPs significantly reduced the gastric ulcer index and increased the ulcer prevention rate. These findings suggest that both nanoparticles offer protection against gastric ulcers. Moreover, CuO-NPs and Fe3O4-NPs exhibited antioxidant properties by decreasing malondialdehyde levels and increasing the activity of superoxide dismutase and nitric oxide, as well as anti-inflammatory effects by reducing tumor necrosis factor-α, interleukin-6, interleukin-1β, myeloperoxidase levels, and increasing prostaglandin E2 levels in serum and gastric tissue, as confirmed by histopathological studies. Both CuO-NPs and Fe3O4-NPs improved ethanol-induced acute gastric ulcers in rats, primarily through their antioxidant and anti-inflammatory activities. These findings suggest the protecting and therapeutic roles of the myco-fabricated CuO-NPs and Fe3O4-NPs from natural and green approaches.
Keywords
Gastric ulcer; Metal oxide; Nanoparticles; myco-fabricated; Albino rats
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