Evaluation of the anti-oxidant and anti-inflammatory effects of ginseng loaded by ZnONP cream on glutaraldehyde-induced dermatitis during infection control. | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 29 April 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.365405.11392 | ||||
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| Authors | ||||
Walaa A. Ali1; Walaa A. Moselhy1, 2; Marwa A. Ibrahim  3; Mohammad S. Mansour4; El-Kady T.S.5; Ahlam G. Khalifa2
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| 1Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, 62511, Egypt. | ||||
| 2Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt | ||||
| 3Department of Biochemistry and Molecular biology, Faculty of Veterinary Medicine,Cairo University, Cairo, Egypt | ||||
| 4Doctor of Inorganic Chemistry at Al-Nasr Company for Intermediate Chemicals, National Service Agency-Ministry of Defense | ||||
| 5Biochemistry Department, Faculty of Agriculture, Al –Azhar University, Cairo, Egypt. | ||||
| Abstract | ||||
| Background This study examined whether local application of natural products (ginseng extract, ginseng-loaded ZnONPs, and ZnONPs alone) can effectively prevent dermatitis in healthcare workers exposed to glutaraldehyde 2% disinfectant during infection control procedures. Materials and methods The experimental design comprised five female mice groups. Group 1 (G1) served as the control group without treatment. Group 2 (G2) was exposed to 2% glutaraldehyde (GLU) spray at a dose of 2 mg/kg body weight. Group 3 (G3) received GLU spray plus topical ginseng extract cream. Group 4 (G4) was treated with GLU spray plus topical zinc oxide nanoparticle (ZnONP) cream. Group 5 (G5) administered GLU spray plus topical ginseng-loaded ZnONP cream. The treatment regimen was administered five days per week over a 30-day period for all experimental animals. Results On the basis of our results, glutaraldehyde-induced dermatitis changed the histological appearance as well as the biochemical parameters by increasing the mRNA expression of TNF-α, IL-1b, nf-kb 1, and ptgs2, and downregulating the mRNA expression of TGFB1. Conclusion Treatment with ginseng-ZnONPs and ZnONPs had a preventive effect on glutaraldehyde across the suppression of oxidative stress and inflammation markers and the augmentation of antioxidants. | ||||
| Keywords | ||||
| FT-IR; TNF-α; IL-6; PTGFB1; ptgs2; nfkb 1; inflammation | ||||
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