The Effect of Alhagi Maurorum (Akool) on Hepatotoxicity in Rats | ||
| مجلة الاقتصاد المنزلي | ||
| Volume 41, Issue 2, June 2025, Pages 23-38 PDF (448.84 K) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/jhe.2025.425134 | ||
| Authors | ||
| Ahmed Hassan Ghanem; Ahmed Ali Ameen; Hany Gaber EL-Masry | ||
| Nutrition and Food Science Department, Faculty of Home Economics, Helwan University | ||
| Abstract | ||
| This study aimed to evaluate the effect of Alhagi Maurorum (Akool) on CCL4- induced hepatotoxicity in rats. Thirty-five rats were separated into two group. The 1st group, rats (n=7) was fed on a basal diet and kept as a negative control group, the 2st group: the hepatotoxic group, rats (n=28), was injected with CCl4 at 1ml/kg b.wt. After 24 h from injection for 3 days, a rat from each group was taken tomeasure liver function to be sure that all rats had liver injury. After liver injury rats were divided as follows: subgroup 1 served as the control positive group and 3 treated rat subgroups were fed on a basal diet supplemented with the A. Maurorum powder concentration (2.5, 5, 10%) per kg of basal diet, respectively. Results revealed that supplementation with different levels of A. Maurorum powder had improved body weight and liver weight accompanied by a significant decrease in levels of liver functions (ALT, AST, ALP and total bilirubin), as well as in lipid profile, while a significant increase in a high-density lipoprotein-cholesterol (HDL-C). In addition, malondialdehyde (MDA) was significantly reduced, while GSH was significantly increased (P<0.05). Conclusion A. Maurorum could introduce a potential natural therapy against hepatotoxicity. | ||
| Keywords | ||
| Alhagi Maurorum; Hepatotoxicity; Liver Disease; Rats | ||
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