Infectious Bursal Disease Virus a Comprehensive Review of Challenges and Advances in Poultry Health. | ||
| Egyptian Journal of Chemistry | ||
| Volume 68, Issue 9, September 2025, Pages 161-181 PDF (515.74 K) | ||
| Document Type: Review Articles | ||
| DOI: 10.21608/ejchem.2025.366754.11422 | ||
| Authors | ||
| Amr H. Abd El-Fatah1; Mahmoud Samir2; M.M. Ali3; Amira Afify3; Omnia S. Shehata* 4; AlKhazindar M.5 | ||
| 1Egyptian Company for Biological & Pharmaceutical Industries (Vaccine Valley), 6th October City, 12511, Giza, Egypt., | ||
| 2Laboratory for Veterinary Quality Control on Poultry Production, Animal Health Research Institute, Agricultural Research Center, Dokki, Giza, 12618, Egypt., | ||
| 3Biotechnology Department, Faculty of Science, Cairo University, Egypt. | ||
| 4Physical Chemistry Department, National Research Centre, Dokki, Giza, Egypt. | ||
| 5Botany and Microbiology Department, Faculty of Science, Cairo University, Egypt. | ||
| Abstract | ||
| Infectious Bursal Disease (IBD), caused by the Infectious Bursal Disease Virus (IBDV), is a highly contagious and economically significant disease affecting poultry worldwide. The disease is characterized by high morbidity rates, variable mortality, and severe impacts on flock productivity. The emergence of very virulent (vvIBDV) and novel variant strains has heightened the complexity of its epidemiology, challenging traditional control measures and vaccination strategies. Since its initial identification in Gumboro, Delaware, in 1962, IBDV has evolved, spreading across continents and generating diverse strains, including recombinant and reassortant forms. These evolutionary dynamics, coupled with the virus’s ability to evade maternal and vaccine-induced immunity, underscore the pressing need for innovative approaches to disease management. This review provides a comprehensive overview of IBDV, focusing on its etiology, epidemiology, pathogenesis, and control strategies. Recent advancements in understanding the virus's evolutionary patterns and the development of novel vaccines are highlighted. Additionally, the review explores the challenges posed by hyper-virulent and variant strains, emphasizing the importance of integrating molecular and epidemiological data to inform effective interventions. By enhancing our knowledge of IBDV, this work aims to support the development of sustainable solutions for mitigating its impact on poultry health, ensuring the productivity and resilience of the global poultry industry. | ||
| Keywords | ||
| Infectious Bursal Disease (IBD); the Infectious Bursal Disease Virus (IBDV); sustainable solutions for mitigating; poultry health | ||
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