A Biochemical Study on Functionality of Body Organs of Rats Fed Various High Milk Proteins Diets | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 7, July 2025, Page 633-645 PDF (2.76 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.364625.11378 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammad Fanoun  1; Elsayed El-Agamy2; Ibrhium Elsayed3; Sameh Awad4
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| 1Department of Food Technology, Palestine Technical University-Kadoorie, Palestine | ||||
| 2Alexandria University Faculty of Agriculture · Department of Dairy Science Ph.D. Immunovirology | ||||
| 3Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Egypt | ||||
| 4Department of Dairy Science and Technology, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt. | ||||
| Abstract | ||||
| A high-protein diet (HPD) is frequently linked to biochemical and physiological alterations in the heart, kidney, and liver, among other important organs. Within the framework of HPD, this study analyzes the effects of various milk proteins and whey protein treatments on organ function and biochemical indicators in rats. The study aimed to evaluate the effects of milk-derived proteins, specifically casein, whey proteins, and both fermented and hydrolyzed milk proteins, on metabolic and enzymatic processes in key organs, while also considering potential risks. The findings of this study indicate that feeding rats a diet high in various forms of milk protein leads to a significant (p≤ 0.0001) decrease in testosterone levels, an increase in high-density lipoproteins (HDL), along with elevated levels of uric acid and urea. However, the study found no significant impact on liver enzymes. Additionally, the albumin/globulin ratio in the blood of rats on a high-protein diet decreased. Overall, the results suggest that high protein intake can worsen existing kidney problems particularly in cases of deteriorated kidney function. While it raises uric acid and urea levels and lowers testosterone levels, it also improves HDL levels. | ||||
| Keywords | ||||
| High-protein diet; milk protein concentrate; whey protein concentrate; liver and kidney functions | ||||
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