Expression of PD-L1 Molecule in Hypopharyngeal and Nasopharyngeal Carcinomas | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 93, Volume 8, Issue 1, January 2025, Page 1053-1063 PDF (663.96 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2025.368786.2147 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Roshdi Hamed Ahmed; Nagwa Abd El-Sadek Ahmed ; Nahawand Mohamed Hafez Elnakib  ; Rasha Mokhtar Abdelkareem
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| Department of Pathology, Faculty of Medicine, Sohag University, Sohag, PO 82524 | ||||
| Abstract | ||||
| Background: Head and neck cancer has the third highest prevalence rate among tumors internationally, with significant rates of mortality and recurrence. The pathway of Programmed Cell Death Protein-1 (PD-1)/ Programmed Cell Death Ligand-1 (PD-L1) is essential in the mechanisms of tumor immune evasion. The expression of PD-L1 is linked to an immunosuppressive microenvironment and has a potential influence on immunotherapy. Objectives: Evaluate the PD-L1 expression in tissue samples of nasopharyngeal and hypopharyngeal carcinomas. Patients and methods: Sections of tissues sourced from 24 patients with hypopharyngeal carcinoma and 20 patients with nasopharyngeal carcinoma were tested for PD-L1 expression by immunohistochemistry. The level of expression was measured by a semi-quantitative scoring system and compared to adjacent normal mucosa. The relation of the PD-L1 expression with pathological and clinical parameters was examined. Results: PD-L1 was found in all investigated tissue samples of both hypopharyngeal and nasopharyngeal carcinoma cases with absent expression in adjacent normal epithelium. PD-L1 histoscore varied from 50 to 280 with a mean (±SD) of 193 (±50) and median of 200. The correlation of PD-L1 expression had a higher grade (P = 0.002) with the advanced stage of hypopharyngeal carcinomas (P = 0.004). Conclusion: Frequent PD-L1 expression in hypopharyngeal and nasopharyngeal carcinoma supports the claim that patients with these tumors could be potential candidates for immunotherapy. | ||||
| Keywords | ||||
| Hypopharyngeal carcinoma; Nasopharyngeal carcinoma; PD-L1 | ||||
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