Ivermectin mitigates lung toxicity induced by γ-radiation in rats via TLR4/ NF-κβ /MAPK pathways | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Volume 38, Issue 1, December 2025, Pages 1-11 PDF (1.24 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2025.326414.1175 | ||
| Authors | ||
| shereen mohamed El Kiki* 1; Shereen Mohamed Galal2; eman mahmoud elgazzar3; Heba Hosney Mansour4 | ||
| 1health radiation research department, national center for radiation research and technology, atomic energy authority | ||
| 2Health Radiation Research Department, National Center for Radiation Research and Technology, Atomic energy authority | ||
| 3bHealth Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt. | ||
| 4Health Radiation Research Department, National Center for Radiation Research and Technology, | ||
| Abstract | ||
| Radiation is capable of inducing reactive oxygen species (ROS), cytokines, chemokines, and growth factors as well as inflammatory cells. Radiation has been termed pro-inflammatory in nature. The current study aims to assess the protective effects of ivermectin against high doses of γ-irradiation by inspecting the effect on inflammatory mediators such as lung receptors toll-like receptors (TLR4), transforming growth factor beta (TGF-β), fibroblast growth factor (FGF), and nuclear factor-kappa B (NF-κβ) in adult male albino rats. Ivermectin was administered orally for 14 days at a dose of 3.7 mg/kg/day and then male albino rats were subjected to a high dose of γ-radiation (30 Gy), which was divided into 10 fractions / five times per week. In addition to increasing the activity of lactate dehydrogenase A (LDHA) in lung tissue, gamma radiation also significantly disrupted the antioxidant system, resulting in lung damage through increased levels of prostaglandin 2 (PGE2), TLR4, TGF-β, NF-κβ, and FGF. In the present work, ivermectin minimized pulmonary damage, through suppression of ROS formation and the restoration of virtually normal levels of FGF, PGE2, TGF-β, NF-κβ, and TLR4 in the lungs, as well as the activities of MAPK and LDHA. The biochemical outcomes were validated by the histological analysis. In conclusion, Ivermectin protects against γ-radiation-induced lung damage by lowering fibroblast differentiation, production of reactive oxygen species and cytokines. Ivermectin mitigates lung damage by modulating TLR4/NF-κβ /MAPK pathways. | ||
| Keywords | ||
| Ivermectin; γ-radiation; TLR4; MAPK; NF-κβ | ||
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