Clinical Utility of Lipid Profile in Antiphospholipid Syndrome | ||||
| Ain Shams Medical Journal | ||||
| Volume 76, Issue 1, March 2025, Page 171-184 PDF (518.65 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2025.339414.1342 | ||||
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| Authors | ||||
Hassan Abdelaty M Elsonbaty1; Ali Ahmed Abou El-Maaty2; Mohammed Abdel-Hassib3; Amr M Hawwash  4
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| 1Rheumatology and Rehabilitation Department, Faculty of Medicine, Helwan University, Cairo, Egypt | ||||
| 2Neurology Department, Faculty of Medicine, Helwan University, Cairo, Egypt | ||||
| 3Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 4Internal medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Antiphospholipid syndrome is a chronic, multi-system autoimmune disorder characterized by thromboembolic events and/or obstetric complications. Exploring associated risk factors is essential in management. Aim of the Work: To study the lipid profile in antiphospholipid syndrome, and the effect of used medications on the lipid profile. Patients and methods: A cross-sectional study was conducted on 70 patients with antiphospholipid syndrome recruited from Rheumatology-Rehabilitation and Neurology outpatient clinics and inpatient wards in four university hospitals. They underwent thorough history taking with complete physical examination. Laboratory investigations included: antiphospholipid markers, complete blood count, erythrocyte sedimentation rate, complement 3, complement 4, and fasting lipid profile. Dedicated imaging modality for diagnosis of arterial or venous thrombotic events Results: Neurological manifestations (specifically migraine, sinus thrombosis and TIAs) showed a significant association with higher cholesterol levels. Sinus thrombosis was associated with lower HDL, higher TG, higher TG/HDL ratio and higher Cholesterol/HDL ratio. Lipid profile showed no statistically significant relation with received medications (Hydroxychloroquine, systemic steroids, and Azathioprine). Conclusion: Dyslipidemia are common in APS especially in patients with TIAs, sinus thrombosis and migraine. No significant relation between medications used in treatment of APS and lipid profile levels. | ||||
| Keywords | ||||
| Antiphospholipid syndrome; lipid profile; systemic lupus erythematosus | ||||
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