Activity of Crude Phenolic Extract from Trigonella to Reduce Side Effects of Paclitaxel Drug on Chromosomal Aberrations, Sperm Parameters, and Sperm DNA Fragmentation | ||||
| Journal of Bioscience and Applied Research | ||||
| Article 11, Volume 11, Issue 2, June 2025, Page 490-501 PDF (581.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2025.354345.1144 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hayder Haqi Ismail1; Majid Shaii Hamdalla   2; Hazim I. Al-Ahmed1
| ||||
| 1Biotechnology Research Center / Al-Nahrain University/Iraq | ||||
| 2Institution of Genetic Engineering and Biotechnique for post-graduate Studies/ Univ. of Baghdad. | ||||
| Abstract | ||||
| Phenols are used to make detergents, a number of prescription medications, herbicides, and other industrial manufactured products. Because they are antioxidants, consuming a collection of phenolic ingredients contained in food lowers the risk of health problems. Paclitaxel is frequently employed in the management of various cancers. High doses of paclitaxel have been demonstrated to be more effective against several forms of cancer. But it has harmful effects on the reproductive system of males. One method of reducing paclitaxel side effects is to administer the medication along with an antioxidant. Methodology: Eighteen albino male rats were divided into 3 groups. Each group contains 6 rats: Group one: Negative control with normal saline injected intraperitoneal. Group two: Positive control Paclitaxel (4 doses at 7mg/kg in 28 days) without plant extract treatment. Group three: Animals were treated with Paclitaxel and crude phenols extract of fenugreek at 10 mg/Kg administration orally, then samples were collected after 28 days. Results: This result showed that phenol extract reduced chromosomal aberrations and DNA fragmentation, while increasing sperm parameters. Conclusion: In this work, we investigate the potential benefits of phenol extract from fenugreek to combat the side effects of the chemotherapeutic agent paclitaxel. | ||||
| Keywords | ||||
| phenols; paclitaxel; chromosomal aberrations; sperm parameters; sperm DNA fragmentation | ||||
|
Statistics Article View: 75 PDF Download: 53 |
||||
