Modulatory Role of Folic Acid against Spleen Dysfunctions Induced by Potassium Bromate in Male Rats (Biochemical and Histological Studies) | ||||
| Journal of Medical and Life Science | ||||
| Article 5, Volume 7, Issue 2, June 2025, Page 197-207 PDF (1.08 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmals.2025.426161 | ||||
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| Authors | ||||
Hadeer M. El-Sayed; Nada S. Badr; Abd El-Fattah B.M. El-Beltagy; Noha M. Samak 
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| Zoology Department, Faculty of Science, Damanhur University, Egypt. | ||||
| Abstract | ||||
| This study investigated the toxic effects of potassium bromate (KBrO₃) on the spleen of male albino rats and evaluated the protective role of folic acid. Twenty-eight adult male rats (120–130 g) were distributed across four distinct groups (n=7): Group I (control), Group II (folic acid, 2 mg/kg/day), Group III (KBrO₃, 50 mg/kg/day), and Group IV (co-administration of folic acid and KBrO₃) for six weeks. Animals were maintained under controlled conditions (12-hour light/dark cycle). Antioxidant enzymes (malondialdehyde, superoxide dismutase, reduced glutathione), immunological markers (CD4, CD8), and trace elements (copper, zinc, phosphorus) were measured in spleen homogenates. KBrO₃ caused significant (P < 0.05) oxidative and immunological toxicity in the spleen, while folic acid treatment markedly reversed these effects, depending upon the dose. These findings suggest that folic acid acts as a potential antioxidant, protecting against KBrO₃-induced spleen toxicity. | ||||
| Keywords | ||||
| Potassium bromate; folic acid; Antioxidant; immunological marker; trace elements | ||||
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