Evaluation of antioxidant and anti-inflammatory activities of Bacillus sp. CZ-Rh4, CZ-Rh7, and CZ-L11 extracts | ||
| Egyptian Journal of Botany | ||
| Article 46, Volume 65, Issue 3, July 2025, Pages 557-566 PDF (1.56 M) | ||
| Document Type: Regular issue (Original Article) | ||
| DOI: 10.21608/ejbo.2025.360059.3191 | ||
| Authors | ||
| Chi Linh Tran* 1; Chong Kim Thien Duc2; Thanh Tan Nguyen2; Duy Toan Pham2; Kim Dinh Phan2; Trang Thi Xuan Dai2; Tuan Trong Nguyen2 | ||
| 1Institute of Food and Biotechnology, Can Tho University, Can Tho City 94000, Vietnam Faculty of Medicine, Nam Can Tho University, Can Tho City 94000, Vietnam | ||
| 2College of Natural Sciences, Can Tho University, Can Tho City 94000, Vietnam | ||
| Abstract | ||
| Bacteria with medicinal potential are receiving research attention from scientists. This study was conducted to explore the in vitro antioxidant and anti-inflammatory potential of extracts from Bacillus sp. CZ-Rh4, Bacillus sp. CZ-Rh7, and Bacillus sp. CZ-L11. Four methods including: 2,2-diphenyl-1-picryl-hydrazyl free radical neutralization, 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) free radical neutralization, total antioxidant capacity, and ferric reducing-antioxidant power were used to evaluate antioxidant activity. Besides, four methods such as: nitric oxide formation inhibition, red blood cell membrane protection, inhibition of bovine serum albumin and egg white albumin denaturation were used to evaluate anti-inflammatory activity. From the results obtained, extracts from endophytic bacterial strains showed good in vitro antioxidant and anti-inflammatory activities. Besides, the in vitro antioxidant and anti-inflammatory activities of the extracts depended on the total polyphenol and flavonoid content. Bacillus sp. CZ-Rh4, Bacillus sp. CZ-Rh7, and Bacillus sp. CZ-L11 were able to produce secondary metabolites as natural sources of antioxidants and anti-inflammatory materials. | ||
| Keywords | ||
| antioxidant; anti-inflammatory; Bacillus sp; endophytic bacteria; flavonoid; polyphenol | ||
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