Evaluation of Triglyceride-Glucose Index as a Marker of Hepatic Steatosis and Fibrosis in Egyptian Patients with NAFLD | ||
| Ain Shams Medical Journal | ||
| Volume 76, Issue 1, March 2025, Pages 220-229 PDF (766.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.343353.1349 | ||
| Authors | ||
| Ahmed Naguib1; Hossam Eldin Mahmoud2; Manal Morsy2; Amina Badr3; Mostafa Elfors* 4 | ||
| 1MD of internal medicine, Lecturer of internal medicine, Hepatology and GIT, Faculty of Medicine, Ain Shams University | ||
| 2MD of internal medicine, Professor of internal medicine, Hepatology and GIT, Faculty of Medicine, Ain Shams University | ||
| 3M.B.B.Ch, faculty of medicine, Ain Shams University, Resident of Internal Medicine, Al Sahel Teaching Hospital, Cairo | ||
| 4MD of Internal Medicine, Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: Non-alcoholic fatty liver disease (NAFLD) grows in frequency, being a significant health burden. A liver histopathology is uncommonly used due to its risks and invasive nature. In order to assess and diagnose NAFLD patients, a trustworthy indicator is needed. An easy and fast method to determine if someone is insulin resistant is to use the triglyceride-glucose (TyG) index. Aim of the Work: Our goal of this research was to examine the relationship between the onset of NAFLD and the TyG index. Methods: Our observational cross-sectional analysis at the hepatology outpatient clinic at Al Sahel Teaching Hospital, from January 2022 to July 2022, was conducted on 100 subjects, divided after history, laboratory results, and ultrasound, into 50 cases with NAFLD and 50 healthy controls. Results: In this study, there was an insignificant difference between both groups as regard age or sex, but the difference was significant between both groups as regard BMI, ALT, fasting blood sugar, TGs, TyG-index, and HOMA IR. Moreover, a noteworthy positive correlation was observed between NAFLD fibrosis score with HOMA-IR and TyG-index, as well as a substantial correlation was noticed between the TyG index and LSM in NAFLD. Conclusion: Our research emphasizes that, in cases of NAFLD, the TyG index might be considered a distinct risk element for both liver fibrosis and hepatic steatosis. The TyG index is low-cost to test and simple to calculate when compared to other IR markers. | ||
| Keywords | ||
| Hepatic steatosis; insulin resistance; NAFLD; triglyceride–glucose index | ||
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