Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma
Abd El-Moeze, N., Abood, D., Hussein, S., Sayed, M. (2025). Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma. EKB Journal Management System, 3(2), 7-16. doi: 10.21608/ejctr.2024.268589.1013
Nadia Ahmed Abd El-Moeze; Doaa Salah Abood; Samia Ibrahim Hussein; Marwa Mohamed Sayed. "Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma". EKB Journal Management System, 3, 2, 2025, 7-16. doi: 10.21608/ejctr.2024.268589.1013
Abd El-Moeze, N., Abood, D., Hussein, S., Sayed, M. (2025). 'Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma', EKB Journal Management System, 3(2), pp. 7-16. doi: 10.21608/ejctr.2024.268589.1013
Abd El-Moeze, N., Abood, D., Hussein, S., Sayed, M. Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma. EKB Journal Management System, 2025; 3(2): 7-16. doi: 10.21608/ejctr.2024.268589.1013

Immunohistochemical Expression of Heat Stable Antigen (CD24) in Renal Cell Carcinoma

Egyptian Journal of Cell and Tissue Research
Volume 3, Issue 2, June 2025, Pages 7-16    PDF (764.69 K)
Document Type: Review articles
DOI: 10.21608/ejctr.2024.268589.1013
Authors
Nadia Ahmed Abd El-Moeze; Doaa Salah Abood* ; Samia Ibrahim Hussein; Marwa Mohamed Sayed
Pathology department, Faculty of Medicine, Beni-Suef University, Egypt
Abstract
Renal cell carcinoma (RCC) is the most common type of urogenital cancer. It has a mortality rate of 30- 40% and is more commonly seen in men than women. Cluster of differentiation (CD)24 is a small, highly glycosylated cell adhesion protein that is normally expressed by immune cells as well as epithelial, neural, and muscle cells. Tumor CD24 expression had been linked with alterations in several oncogenic signaling pathways. The aim of our work to evaluate the immunohistochemical expression of CD24 in RCC and detect its relationship with other clinicopathological parameters. Thirty-nine (39) cases (97.5%) showed positive CD24 expression while single case (2.5%) was negative. Score 0 was seen in this single case (2.5%), score +1 was seen in 18 cases (45%), score +2 in 16 cases (40%) and score +3 was seen in 5 cases (12.5%). High CD24 expression had been presented in (52.5%) of cases. There was no significant correlation between CD24 expression and other clinicopathological parameters such as age, gender, histological subtype, tumor grade, pathological tumor stage, lymph node status, capsular invasion, tumor necrosis and lymphovascular emboli
Keywords
Renal cell carcinoma; urogenital cancer, CD24 expression
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