Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus | ||
| Ain Shams Medical Journal | ||
| Volume 76, Issue 1, March 2025, Pages 247-256 PDF (700.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.335764.1339 | ||
| Authors | ||
| Ali Abd El-hakam El-Hayes1; Shady Mohamed Hassan Soliman2; mohamed khaled abo-elnour* 3; Khaled El-Ghonemy Said Ahmed4 | ||
| 1Ophthalmology Department, Faculty of Medicine - Menoufia University - Menoufia - Egypt | ||
| 2Cornea unit, Research Institute of Ophthalmology (RIO) - Giza - Egypt | ||
| 3Researcher master's degree in Ophthalmology, Ophthalmology Department,, Faculty of Medicine - Menoufia University, Menoufia , Egypt. | ||
| 4Ophthalmology Department, Faculty of Medicine - Menoufia University - Menoufia - Egypt | ||
| Abstract | ||
| Background: Corneal cross-linking is the most used strategy to treat keratoconus, aims to slow down even arresting the progression of the disease. Although collagen CXL is considered safe and effective procedure, CXL can cause endothelial failure, with significant corneal edema, and patients may require penetrating keratoplasty based on the extent of endothelial damage. Objectives: To evaluate the corneal endothelial cell changes by Specular microscopy, after Cross-linking of the cornea in keratoconus cases, as a comparison of the Accelerated Protocol and the Standard Dresden Protocol. Patients and Methods: This study is a prospective study, performed on twenty-two keratoconus-afflicted eyes of both sexes at ophthalmology Department, Faculty of Medicine, Menoufia University, in partnership with cornea and refractive units, Giza Research Institute of Ophthalmology, during the period from February 2023 to April 2024. Patients were divided into two groups as follows: Group (I) underwent accelerated protocol, and Group (II) underwent Standard Dresden protocol. Results: The groups under study did not differ significantly regarding density of corneal endothelial cells, average area, coefficient of variation, hexagonal cells, and thickness of cornea (P>0.05). Conclusion: Corneal CXL with Riboflavin and UV-A irradiation stops progression of KC in all eyes. The use of accelerated CXL had the same impact on corneal endothelium as conventional CXL. | ||
| Keywords | ||
| Accelerated; Corneal cross-linking (CXL); Dresden; Keratoconus | ||
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