Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus
El-Hayes, A., Soliman, S., abo-elnour, M., Said Ahmed, K. (2025). Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus. EKB Journal Management System, 76(1), 247-256. doi: 10.21608/asmj.2025.335764.1339
Ali Abd El-hakam El-Hayes; Shady Mohamed Hassan Soliman; mohamed khaled abo-elnour; Khaled El-Ghonemy Said Ahmed. "Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus". EKB Journal Management System, 76, 1, 2025, 247-256. doi: 10.21608/asmj.2025.335764.1339
El-Hayes, A., Soliman, S., abo-elnour, M., Said Ahmed, K. (2025). 'Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus', EKB Journal Management System, 76(1), pp. 247-256. doi: 10.21608/asmj.2025.335764.1339
El-Hayes, A., Soliman, S., abo-elnour, M., Said Ahmed, K. Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus. EKB Journal Management System, 2025; 76(1): 247-256. doi: 10.21608/asmj.2025.335764.1339

Corneal Endothelium Specular Microscopic Changes in Different Protocols of Collagen Cross Linking in Keratoconus

Ain Shams Medical Journal
Volume 76, Issue 1, March 2025, Page 247-256  XML PDF (700.9 K)
Document Type: Original Article
DOI: 10.21608/asmj.2025.335764.1339
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Authors
Ali Abd El-hakam El-Hayes1; Shady Mohamed Hassan Soliman2; mohamed khaled abo-elnour email 3; Khaled El-Ghonemy Said Ahmed4
1Ophthalmology Department, Faculty of Medicine - Menoufia University - Menoufia - Egypt
2Cornea unit, Research Institute of Ophthalmology (RIO) - Giza - Egypt
3Researcher master's degree in Ophthalmology, Ophthalmology Department,, Faculty of Medicine - Menoufia University, Menoufia , Egypt.
4Ophthalmology Department, Faculty of Medicine - Menoufia University - Menoufia - Egypt
Abstract
Background: Corneal cross-linking is the most used strategy to treat keratoconus, aims to slow down even arresting the progression of the disease. Although collagen CXL is considered safe and effective procedure, CXL can cause endothelial failure, with significant corneal edema, and patients may require penetrating keratoplasty based on the extent of endothelial damage.
Objectives: To evaluate the corneal endothelial cell changes by Specular microscopy, after Cross-linking of the cornea in keratoconus cases, as a comparison of the Accelerated Protocol and the Standard Dresden Protocol.
Patients and Methods: This study is a prospective study, performed on twenty-two keratoconus-afflicted eyes of both sexes at ophthalmology Department, Faculty of Medicine, Menoufia University, in partnership with cornea and refractive units, Giza Research Institute of Ophthalmology, during the period from February 2023 to April 2024. Patients were divided into two groups as follows: Group (I) underwent accelerated protocol, and Group (II) underwent Standard Dresden protocol.
Results: The groups under study did not differ significantly regarding density of corneal endothelial cells, average area, coefficient of variation, hexagonal cells, and thickness of cornea (P>0.05).
Conclusion: Corneal CXL with Riboflavin and UV-A irradiation stops progression of KC in all eyes. The use of accelerated CXL had the same impact on corneal endothelium as conventional CXL.
Keywords
Accelerated; Corneal cross-linking (CXL); Dresden; Keratoconus
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