Extra Virgin Olive Oil Protected Against Hyperthyroidism-Induced Cardiac Dysfunction Via Reduced Angiotensin-II Receptor Expression in Adult Male Rats | ||
| Ain Shams Medical Journal | ||
| Volume 76, Issue 1, March 2025, Pages 284-302 PDF (1.43 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.359505.1387 | ||
| Authors | ||
| manal Said Abd el hamid* 1; Nermine Saleh2; doaa abou-bakr3; hanan saleh4; eman mousa5; Abd El-Hamid mohamed6 | ||
| 1Ain Shams university, Faculty of medicine, medical physiology, Asisstant professor, cairo, Egypt | ||
| 2Ain Shams university, faculty of medicine, professor of physiology | ||
| 3Ain shams university, faculty of medicine, Assistant professor physiology | ||
| 4Ain Shams university, faculty of medicine , histology professor | ||
| 5Ain shams university, faculty of medicine, assisstant lecturer of physiology | ||
| 6Ain shams university, faculty of medicine, physiology assistant professor | ||
| Abstract | ||
| Background: Hyperthyroidism-induced cardiac dysfunction is a common disorder that was linked to the interplay between oxidative stress and activated renin-angiotensin system. Studies related the consumption of extra virgin olive oil (EVOO) to the lower risk of cardiovascular diseases. Aim of the Work: So, this study aimed to evaluate the cardioprotective effects of extra virgin olive oil (EVOO) in experimentally induced hyperthyroidism with possible involvement of angiotensin-II receptor 1 (Ang-II-R1) and the antioxidant hemeoxygenase-1 (HO-1) enzyme. Methods: Thirty adults male Wistar rats, allocated into 3 groups, control, Hyperthyroid group; received intraperitoneal injection of 100μg/kg L-thyroxine daily for 4 consecutive weeks, EVOO-treated hyperthyroid group; received L-thyroxine as in group II, then by the beginning of the third week, 1ml/100g EVOO by gavage daily for 2 weeks. Results: EVOO-treated hyperthyroid rats showed significant body weight reduction with PR interval restoration near the control level. EVOO resulted in significant reduction in Ang-II-R mean % area and optical density with consequent reduction in the cardiac HO-1. This reduction was correlated with the improvement in basal cardiac inotropic function and cardiac inotropic response following isoproterenol infusion together with partial reversal of the hyperthyroid induced histological changes. Conclusion: Prophylactic use of EVOO in hyperthyroidism could minimize the cardiac dysfunction and structural alterations by reducing Ang-II-R1 overexpression and mitigating oxidative stress. | ||
| Keywords | ||
| Ang-II-R1; cardiac dysfunction; extra virgin olive oil; hyperthyroidism; HO-1 | ||
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