Biological activity of ethanol extract from brown algae Sargassum plagiophyllum application in pharmaceutical cosmetics | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.343043.2386 | ||||
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| Authors | ||||
Hong Phien Huynh1; Hong Phan Huynh2; Quoc Cuong Nguyen3; Men Tran Thanh  4
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| 1Department of Biology, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam | ||||
| 2College of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho 94000, Vietnam | ||||
| 3Department of Health Sciences, College of Natural Sciences, Can Tho University, Can Tho 94000, Vietnam | ||||
| 4Department of Biology, College of Natural Sciences, Can Tho University, Viet Nam | ||||
| Abstract | ||||
| Background: Natural compounds derived from brown seaweed are gaining attention in skincare due to their antioxidant, antibacterial, and UV-protective properties. This study explored the potential of Sargassum plagiophyllum as a source of bioactive compounds for treating skin conditions. Methods: Ethanol extract was prepared and analyzed for flavonoid and phlorotannin content. Antioxidant activity was assessed using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) (ABTS) assays, while antibacterial effects against Staphylococcus aureus, Propionibacterium acnes, and Pseudomonas aeruginosa were examined through the disc diffusion method. Anti-inflammatory activity was measured using the BSA denaturation assay, UV protection was evaluated via SPF measurement, and tyrosinase inhibition was tested for skin-whitening potential. Results: The extract was found to be rich in flavonoids (366.38±5.47 mg QE/g extract) and phlorotannins (53.39±0.79 mg GAE/g extract). Antioxidant tests showed EC50 values of 1.933±0.192 mg/mL (DPPH) and 0.301±0.008 mg/mL (ABTS). The extract exhibited notable antibacterial activity against P. acnes with a 4.33±0.29 mm inhibition zone at 10.24 mg/mL. UVB protection was effective, with an SPF of 17.60±0.12 at 1000 µg/mL. Additionally, the extract displayed anti-inflammatory properties (IC50 = 765±0.5 µg/mL) and tyrosinase inhibition (IC25 = 15.03 µg/mL). Conclusion: These findings suggest that S. plagiophyllum extract is a promising natural ingredient with antioxidant, antibacterial, anti-inflammatory, anti-tyrosinase, and UV-protective effects, making it a valuable candidate for skincare and pharmaceutical applications. | ||||
| Keywords | ||||
| Sargassum plagiophyllum; antibacterial; anti-inflammatory; anti-oxidant; anti-UV | ||||
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