"Antibiotic Sensitivity pattern and Microbial Profile in Catheter-Related Bloodstream Infections at a University Hospital" | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 06 May 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2025.367274.2616 | ||
| Authors | ||
| Shymaa Hassan Yahia* 1; Rasha Abdalla Wadan2 | ||
| 1Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt | ||
| 2Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Catheter-related bloodstream infections (CRBSIs) are a substantial and ongoing concern in clinical settings, especially in intensive care units (ICUs). Such infections not only lengthen hospital stays and raise healthcare expenses, but they also pose major risks to patient health, resulting in high morbidity and fatality rates. Determining the antibiotic sensitivity and microbial profiles of infections that cause CRBSIs is critical for creating efficient therapy methods and optimizing patient outcomes. This study aims to determine the microbiological culprits in central line-related bloodstream infections and analyze the antibiotic sensitivity patterns of the isolates. Methods: This study included 119 ICU patients with central line bloodstream infections. Blood samples were taken from the catheter lumen and peripheral vein and processed using the automated BacT/ALERT® 3D 60 (BioMérieux, France). The identification of the isolates and their antibiotic sensitivity pattern was done by VITEK 2® COMPACT (bioMérieux, Marcy-l'Étoile, France). Results: Klebsiella pneumoniae (52.1%) was the most common isolated bacteria causing CVC-BSI, followed by S. aureus (18.5%), Pseudomonas aeruginosa (7.6%), and E. coli (6.7%). All S. aureus isolates (n=22), 100%, were MRSA. 68% of isolated bacteria were MDR (75), and 32 % were non-MDR (36). 93% of Klebsiella pneumoniae isolates were carbapenem-resistant (58), with 52% being serine carbapenemase producers (30) and 48% being metallo-beta-lactamase producers (28). Conclusion: K. pneumoniae is the most prevalent pathogen causing CRBSIs, with 93% being carbapenem-resistant. The high prevalence of MRSA and the increasing frequency of multidrug-resistant (MDR) infections are alarming. | ||
| Keywords | ||
| Key words: catheter; bloodstream; infection; antibiotic sensitivity | ||
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