Therapeutic Potential of γ-Irradiated Chlorella vulgaris Against Helicobacter pylori-Induced Testicular Damage in Rats | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.358618.2532 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohammed Mohammed1; Maha Jasim1; Fathy El-Saied2; Helal Moussa   3; Abd El-Fatah Ahmed4; Mona Mohamed2; Mai Maize2
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| 1Al-Dour Technical Institute, Northern Technical University, Iraq. | ||||
| 2Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koom, Egypt. | ||||
| 3Radioisotope Department, Nuclear Research Center, Atomic Energy Authority, Egypt. | ||||
| 4Radioisotope Department, Nuclear Research Center, Atomic Energy Authority, Egypt | ||||
| Abstract | ||||
| Background: The infection with Helicobacter pylori is linked to various diseases. Aim: Investigation of therapeutic potential of γ-irradiated Chlorella vulgaris against Helicobacter pylori-induced testicular damage in rats. Methods: Rats were divided into four groups. Group I. represents the control. rats. Group II. rats received γ-irradiated Chlorella vulgaris (200 Gy) as food. Group III. rats were infected by H. pylori. Group IV. H. pylori-infected rats received γ-irradiated Chlorella vulgaris. The experimental period is sex weeks. Results: The amino acid and polyphenol levels of γ-irradiated Chlorella vulgaris increased significantly as compared to the control. H. pylori infections significantly increased the hormonal levels of FSH (51.8%) and LH (136%) as compared to the control. Also, reduced testosterone levels (50.35%) as compared the control. Meanwhile, application of γ-irradiated Chlorella vulgaris dramatically increased the hormonal level of testosterone in contrast to the group of rats infected with H. pylori. Also, they decreased to some extent the levels of LH and FSH in contrast to the group of rats infected with H. pylori. The testicular section of the H. pylori-infected rat showed vascular degeneration, thickening of the tubule basement membrane, hemorrhage in interstitial tissues, a marked decrease in the population of spermatogenic cells, and Leydig cell deformation. However, treatment with Chlorella vulgaris demonstrated healthy spermatogenic cells with normal arrangements which was more or less similar to the control. Conclusion: The findings suggest that C. vulgaris could be a natural, safe, and cost-effective therapeutic agent making it a viable natural medicinal medication against H. pylori-induced oxidative damage. | ||||
| Keywords | ||||
| Polyphenols; C. vulgaris; H. pylori; Testicular histology; Oxidative stress | ||||
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