Combined Effects of Gallic Acid and Quercetin on L-NAME-Induced Hypertensive Rats | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 07 May 2025 PDF (1.91 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.365364.2675 | ||
| Authors | ||
| Nada Samir Ibrahim Ahmed1; mohamed ali maher eladl* 2; Gehad EL-Sayed3; Mohamed Metwally4; El-Said El-Sherbini5 | ||
| 1biological chemistry and molecular biology | ||
| 2biochemistry and molecular biology ,faculty of veterinary medicine , Mansoura university | ||
| 3Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University | ||
| 4Faculty of veterinary Medicine, Mansoura University | ||
| 5Department of Biochemitry nd Molecular Biology, Veterinary Medicine, Mansoura University | ||
| Abstract | ||
| Hypertension is one of the most risky health conditions so in this current study, results evaluated the protective impacts of Gallic acid and Quercetin as herbal products on cardiovascular disorders, mainly hypertension in male rats. Five groups equal in number of rats (n=10) were parted. In the control negative (Ct-ve) group, rats were obtained only a normal feed ration. In the control positive (CT=ve) group, rats were received L-NAME (50 mg/kg/day) for inducing a hypertensive model. The Gallic acid group rats were received L-NAME for three weeks, then were given therapeutic dose of Gallic acid for five weeks for treatment (100 mg/kg of rats daily orally). The Quercetin group, rats were given Quercetin for five weeks by a dose of (10 mg/kg.bw, orally, daily); 10 mg/kg.bw orally daily; and the combination group was given both Gallic acid and quercetin.. Finally, in our study, serum, heart tissue, and aorta were gathered for detection of cardiac damage markers (CK-mb and LDH), antioxidant activity (catalase, NO, MDA, and GSH), and lipid profile (TC, TAG, HDL-C, LDL-C and VLDL-C). Heart and aorta tissue were collected for histopathology. The result has been demonstrated that gallic acid plays a role for the treatment of hypertension and acts as an antioxidant agent as it decreases NO level and lipid profile. Quercetin showed a small difference in the result of the cardiac damage marker and level of NO, and the lipid profile showed a decrease compared to the control positive group. The combination group showed the best result to decrease hypertension. | ||
| Keywords | ||
| Hypertension; L-NAME; Gallic acid; Quercetin; Biochemical and Pathological alterations | ||
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