Role of Liposome as an Adjuvanted Antigen Delivery System in Enterotoxaemia Vaccine in Rabbit | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 07 May 2025 PDF (1 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.369847.2720 | ||
| Author | ||
| Riham Mohamed wahied EL-DIN* | ||
| veterinary serum and vaccine research ,Abassia,cairo,Egypt | ||
| Abstract | ||
| Enterotoxaemia disease in weaned rabbits has a significant impact on the rabbit industry. Clostridium perfringens type A caused an enterotoxaemia disease accompanied by severe bloat with brownish diarrhea and high mortalities. This study aims to compare the potency of a newly formulated enterotoxaemia vaccine and that of the presently available vaccine. Two types of enterotoxaemia vaccines were prepared from a toxigenic strain of Clostridium perfringens (CP) type A namely CP/liposome vaccine and CP/aluminum hydroxide gel vaccine. One received aluminum hydroxide vaccine in 2 doses (2 ml S/C with 3 weeks interval) and the other 2 groups, CP/liposome vaccine received liposome vaccine as one-shot dose (G2) and one as a control unvaccinated group (G3). Humoral immunity was quantified using indirect enzyme-linked immunosorbent assay (ELISA) and serum neutralization test. Out of two vaccines evaluated, CP/liposome vaccine produced higher protection till 11 months without any booster dose and no vaccinal reactions observed at injection site while the aluminum hydroxide gel vaccine give protection till 6 months. So, the study concluded the synergistic role of the prepared CP/liposome adjuvanted vaccine in eliciting a higher and persistent immune response and its superiority over the currently available vaccine. | ||
| Keywords | ||
| Aluminum hydroxide gel; C. perfringens type A; ELISA; liposome; Serum neutralization test | ||
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