Impact of Harmala (Peganum harmala, L.) Seeds on Biological, Biochemical and Histopathological Alternations of Alloxan–Induced Diabetic Rats | ||||
| مجلة بحوث التربية النوعية | ||||
| Volume 2025, Issue 92, May 2025, Page 639-666 PDF (1.03 MB) | ||||
| Document Type: مقالات علمیة محکمة | ||||
| DOI: 10.21608/mbse.2025.352827.1575 | ||||
 View on SCiNiTO | ||||
| Author | ||||
زينب سيد احمد احمد الغطريفى 
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| كلية التربية النوعية - جامعة اسيوط - محافظة اسيوط | ||||
| Abstract | ||||
| The goal of the current study was to ascertain the effects of Harmala seed powder and extract rats that had been given alloxan to induce diabetes. Thirty-six white randoms weighing between 140 and 150 g were randomly divided into two main groups of six. Group I was the randomized control group, while Group II received a single intra-cage injection of the diabetic medication alloxan (150 mg/kg b.wt.). Next, the diabetic rats in Group II were randomly divided into seven subgroups: For four weeks, groups 3-6 received the ordinary food plus 2.5 and 5% Harmala seed powder, as well as 250 and 500 mg/kg. Group 2, the diabetic group serving as the positive control, received only the standard diet. Twenty-eight days after the trial started samples were analyzed for biochemical indicators such as blood parameters (RBCs, WBCs, HGB, and PLT), lipid fractions (TC, TG, HDL-c, LDL-c, and VLDL-c), renal function (urea, uric acid, and creatinine), liver enzymes (ALT, AST, and ALP), and glucose and insulin concentrations. The obtained data showed that the studied plants (P≤0.05) decreased serum sugar, LDL-c, and HDL-c when compared to the control positive group. The plants under study also improved blood parameters, liver, and kidney function. According to our research, the powdered Harmala seeds and their extract include several potent phytochemical substances that may help reduce side effects and regulate diabetic rats. | ||||
| Keywords | ||||
| Rats; harmala seeds; hyperglycemia; biochemical analysis | ||||
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