The Role of Feed Restriction on Hematological, Biochemical, and Histopathological Alterations in the Liver and Kidney of Adult Male Rats | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 10 May 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.365908.11404 | ||||
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| Authors | ||||
Manal R. Bakeer   ; Marina M. Ibrahim; E. seifelnasr
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| Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Egypt. | ||||
| Abstract | ||||
| Feed restriction (FR) is a dietary intervention that influences various physiological processes, including hematological and biochemical profiles, as well as organ histopathology. This study aimed to investigate the effects of different levels of feed restriction (30% and 60%) on hematological indices, blood biochemical parameters, and histopathological changes in the liver and kidneys of adult male rats. Thirty Swiss albino male rats were assigned to three groups: a control group with ad libitum feeding, a 30% feed restriction group, and a 60% feed restriction group, maintained for two months. The results demonstrated a significant decline (p < 0.05) in red blood cell count, white blood cell count, hemoglobin concentration, and platelet count in both restricted groups, with the most pronounced reductions observed in the 60% FR group. Biochemical analysis revealed significant decreases (p < 0.05) in cholesterol, triglycerides, and glucose levels, along with elevated ALT and AST levels in the restricted groups, while ALP levels decreased significantly (p < 0.05). Additionally, creatinine levels were significantly reduced (p < 0.05) in the 60% FR group, whereas uric acid and urea levels increased significantly (p < 0.05). Histopathological analysis indicated hepatic necrosis, vacuolar degeneration, and hepatocellular atrophy in the liver, while the kidneys exhibited severe glomerulopathy, tubulonephritis, and tubular necrosis, particularly in the 60% FR group. These findings suggest that excessive feed restriction can have detrimental effects on hematological, biochemical, and histopathological parameters, emphasizing the need for balanced dietary intake to maintain physiological homeostasis. | ||||
| Keywords | ||||
| Feed restriction; hematology; biochemical parameters; histopathology; liver; kidney | ||||
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