The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery
Mansour, M., Mohamed, A., El sharawy, A. (2025). The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery. EKB Journal Management System, 6(2), 63-77. doi: 10.21608/ejmr.2023.207138.1383
Mariana Abdelsayed Mansour; Arwa Khaled Mohamed; Ahmed Mostafa El sharawy. "The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery". EKB Journal Management System, 6, 2, 2025, 63-77. doi: 10.21608/ejmr.2023.207138.1383
Mansour, M., Mohamed, A., El sharawy, A. (2025). 'The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery', EKB Journal Management System, 6(2), pp. 63-77. doi: 10.21608/ejmr.2023.207138.1383
Mansour, M., Mohamed, A., El sharawy, A. The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery. EKB Journal Management System, 2025; 6(2): 63-77. doi: 10.21608/ejmr.2023.207138.1383

The use of postoperative intravenous patient-controlled analgesia with low dose versus standard dose Morphine in children undergoing pelvic-abdominal exploration surgery

Egyptian Journal of Medical Research
Volume 6, Issue 2, April 2025, Page 63-77  XML PDF (507.69 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2023.207138.1383
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Authors
Mariana Abdelsayed Mansour; Arwa Khaled Mohamed email ; Ahmed Mostafa El sharawy
Anesthesiology, surgical intensive care and pain management department Faculty of Medicine, Beni-Suef University Egypt
Abstract
Background: Patient-controlled analgesia is an effective method used to alleviate pain in children. Morphine is the standard opium-based analgesic used; however, its use is usually associated with adverse effects that may be severe. This study was carried out to evaluate the efficacy and safety of low-dose Morphine in controlling acute pain in children undergoing exploration surgery. Methods: This study was conducted at Beni-Suef University Hospital on 46 patients. The patients were divided randomly into two equal groups: The standard dose morphine group: Which received 0.05 mg morphine /kg/dose, and the low dose morphine group: Which received 0.01 mg morphine /kg/dose. During post-operative follow-up, the pain was assessed using VAS and VRS in addition to POSS sedation score and follow-up of adverse events. Results: There was no significant difference between the groups' mean VAS and VRS pain scores and their categories. However, the side effects of Morphine, like PONV and respiratory depression, were significantly decreased in the low-dose morphine group.  Conclusions: The present study shows that both the low dose and the standard dose of Morphine could effectively control the post-operative pain in patients-controlled analgesia of children undergoing pelvic-abdominal exploration surgeries with a lower incidence of postoperative complications in the low-dose morphine group. 
 
Keywords
Morphine; PCA; Low dose morphine
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