Toxicological Effect of Energy Drinks on Pancreatic Tissues and Induction of Metabolic Disorders Diseases in Adult Pregnant and Lactated Female Rats | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 11 May 2025 PDF (935.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.362033.2653 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Demiana Badry Hanna   1; Fatma El-zahraa Salama1; Mohamed A. A. El Desouky2; Heba Ali Abd El Rahman3
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| 1Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt. | ||||
| 2Chemistry department, faculty of science, Cairo University | ||||
| 3Zoology Department, Faculty of Science, Cairo University, Giza, Egypt | ||||
| Abstract | ||||
| Energy drinks (EDs) are the most purchased drink among youth worldwide. They can cause many adverse effects, including pancreatitis and pancreas damage, and increase the risk of having type 2 diabetes and obesity. Until now, there has been an information gap about their effect on females' body health during their gestation and lactation. The current research seeks to evaluate the potential toxicity of EDs on the metabolic health of pregnant and lactating female rats. Eighteen female Wistar rats were divided into three groups and administered daily from the fifth day of pregnancy until the end of lactation orally with saline solution in the control group, 3.57 ml/kg of body weight in the low dose group, and 7.14 ml/kg of body weight in the high dose group. EDs-supplied groups caused a significant increase (p<0.05) in glucose, HOMA-IR, and pancreas exocrine enzymes (lipase, amylase) production and triggered lipid disturbances compared to the control. Moreover, the finding indicated a marked drop (p<0.05) in the insulin secretion level of both EDs treated groups. EDs impair the activity of antioxidant enzymes while inducing the activity of malondialdehyde (MDA) and pancreas DNA damage. The pancreatic tissue of female-treated rats showed various histopathological abnormalities. EDs induced toxicity effects in the gestated and lactated mother on the pancreatic tissue at the level of morphology and DNA, enhancing the risk of developing metabolic disorders. All these outcomes had a detrimental influence on the health of maternal rats. | ||||
| Keywords | ||||
| Energy drinks; Pancreas; Metabolic Syndrome; Oxidative biomarkers; Histopathology | ||||
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