Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries
Mortagy, M., Abdeltawab, M., Taher, A., shafik, Y., El Fawy, D. (2025). Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries. EKB Journal Management System, (), -. doi: 10.21608/arcmed.2025.358217.1092
Mahmoud Mortagy; Mahmoud Abdeltawab; Amr Taher; yasser shafik; Dalia El Fawy. "Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries". EKB Journal Management System, , , 2025, -. doi: 10.21608/arcmed.2025.358217.1092
Mortagy, M., Abdeltawab, M., Taher, A., shafik, Y., El Fawy, D. (2025). 'Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries', EKB Journal Management System, (), pp. -. doi: 10.21608/arcmed.2025.358217.1092
Mortagy, M., Abdeltawab, M., Taher, A., shafik, Y., El Fawy, D. Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries. EKB Journal Management System, 2025; (): -. doi: 10.21608/arcmed.2025.358217.1092

Comparison between Intravenous Ibuprofen and Ketorolac for intraoperative and postoperative analgesia in breast surgeries

ARCADEs of MEDICINE
Articles in Press, Accepted Manuscript, Available Online from 12 May 2025  XML
Document Type: Original Research
DOI: 10.21608/arcmed.2025.358217.1092
View on SCiNiTO View on SCiNiTO
Authors
Mahmoud Mortagy1; Mahmoud Abdeltawab1; Amr Taher email 2; yasser shafik1; Dalia El Fawy1
1Anesthesia, Surgical Intensive Care and Pain Management Department, Armed Forces College of Medicine, Cairo, Egypt
2Faculty of pharmacy (clinical pharmacy program ), Cairo University, Cairo, Egypt
Abstract
Background: Effective postoperative pain management is essential, but concerns over opioid overprescription have increased interest in non-opioid alternatives like NSAIDs. This study compares the analgesic effects of intravenous (IV) ketorolac and ibuprofen in women undergoing breast excisional biopsy or mastectomy.



Methods: A total of 54 patients at Maadi Military Hospital, Cairo, Egypt, were randomized into two groups: 27 received IV ibuprofen (400–800 mg every 20 minutes, up to 3200 mg/day), and 27 received IV ketorolac (30 mg every hour, up to 120 mg/day). Pain was assessed using the Visual Analogue Scale (VAS), opioid consumption, and hemodynamic stability.



Results: The ketorolac group had a significantly shorter early recovery time and lower pain scores at multiple time points (4, 12, 16, 20, and 24 hours; p<0.05). Baseline VAS scores were also lower in this group. Patients receiving ketorolac spent less time in the post-anesthesia care unit (PACU), though hospital stays were similar. Both groups maintained hemodynamic stability, but ketorolac was associated with fewer adverse events.



Conclusion: IV ketorolac provides superior postoperative analgesia compared to IV ibuprofen in women undergoing breast surgeries, with faster recovery, lower pain scores, and fewer side effects.
Keywords
pain management, NSAID'; s, mastectomy, analgesics
Statistics
Article View: 54